Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls produced a comprehensive dataset of the variations causing susceptibility to systemic lupus erythematosus (SLE). Two independent disease association signals in the HLA-D region identified two regulatory regions containing 3562 polymorphisms that modified thirty-seven transcription factor binding sites. These ex...

The aim of the present study was to examine specifically whether the relationship between coping style and symptoms of whiplash injury change as a function of gender. A total of 1709 sufferers of whiplash associated disorder (1349 women, 360 men) belonging to the Danish Society for Polio, Traffic and Accident Victims completed questionnaires measuring demographic and psychological factors (incl...

NMDA receptor (NMDAR) composition and synaptic retention represent pivotal features in the physiology and pathology of excitatory synapses. Here, we identify Rabphilin 3A (Rph3A) as a new GluN2A subunit-binding partner. Rph3A is known as a synaptic vesicle-associated protein involved in the regulation of exo- and endocytosis processes at presynaptic sites. We find that Rph3A is enriched at dend...

The 32-kDa photosystem II protein of the chloroplast is thought to be a target molecule for the herbicide atrazine. The psbA gene coding for this protein was cloned from Solanum nigrum atrazine-susceptible ('S') and atrazine-resistant ('R') biotypes. The 'S' and 'R' genes are identical in nucleotide sequence except for an A to G transition, predicting a Ser to Gly change at codon 264. The same ...

We encountered a clinical problem in a young man who presented with a left upper lobe mass and a diffuse reticular-nodular infiltrate. We thought we had appropriately applied Murphy’s Law (the famed bank robber who “went where the money is”), and Ockham’s Razor (the philosopher William of Ockham [1285 to 1349]“Entities are not to be multiplied beyond necessity”) as we rapidly diagnosed the lung...

The ERD2 gene, which encodes the yeast HDEL (His-Asp-Glu-Leu) receptor, is essential for growth (Semenza, J. C., K. G. Hardwick, N. Dean, and H. R. B. Pelham. 1990. Cell. 61:1349-1357; Lewis, M. J., D. J. Sweet, and H. R. B. Pelham. 1990. Cell. 61:1359-1363). SED5, when present in multiple copies, enables cells to grow in the absence of Erd2p. Sequence analysis of SED5 reveals no significant ho...

Mid and far infrared maps of many Galactic star forming regions show multiple peaks in close proximity , implying more than one embedded energy sources. With the aim of understanding such interstellar clouds better, the present study models the case of two embedded sources. A radiative transfer scheme has been developed to deal with an uniform density dust cloud in a cylindrical geometry, which...

INTRODUCTION..................................................................................................... 1325 I. CONTRACTING AT THE IPO STAGE ................................................................. 1331 A. IPO Charters and Takeover Defenses ...................................................... 1332 B. Innovation, Diversity, and the “Plain Vanilla” Charter ......................

Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis 1 2 Valter F. de Andrade-Neto, 1-3 Tito da Silva, 4 Lucia M. Xavier Lopes, 4* Virgílio E. do Rosário, 5 3 Fernando de Pilla Varotti, 1 and Antoniana U. Krettli 1 4 5 6 Laboratório de Malaria, Centro de Pesquisas René Rachou/FIOCRUZ, 30190-002, Belo Horizonte, 7 MG, Brazil; 1 Departamento de Parasitologia, Universidade F...