The TetR family of transcriptional regulators is ubiquitous in bacteria, where it plays an important role in bacterial gene expression. Streptococcus mutans, a gram-positive pathogen considered to be the primary etiological agent in the formation of dental caries, encodes at least 18 TetR regulators. Here we characterized one such TetR regulator, SMU.1349, encoded by the TnSmu2 operon, which ap...

Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1344 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Geographical distribution and type of units . . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Location . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Type of intervention according to different levels of care . . . . . . . . . . . . . . ....

Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1344 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Geographical distribution and type of units . . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Location . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Type of intervention according to different levels of care . . . . . . . . . . . . . . ....

Cytochrome P450 is a family of enzymes that catalyze reactions involved in the metabolism of drugs and other xenobiotics. These enzymes are therefore important in pharmacologic and toxicologic studies, and information on their abundances is of value in the process of scaling in vitro data to in vivo metabolic parameters. A meta-analysis was applied to data on the abundance of human hepatic cyto...

Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally linked to nephropathy. Thrombomodulin-dependent APC formation mediates cytoprotection in diabetic neph...

Miguel Angel Pujana1,2,16,17, Jing-Dong J Han1,2,16,17, Lea M Starita3,16,17, Kristen N Stevens4,17, Muneesh Tewari1,2,16, Jin Sook Ahn1,2, Gad Rennert5, Vı́ctor Moreno6,7, Tomas Kirchhoff 8, Bert Gold9, Volker Assmann10, Wael M ElShamy2, Jean-François Rual1,2, Douglas Levine8, Laura S Rozek6, Rebecca S Gelman11, Kristin C Gunsalus12, Roger A Greenberg2, Bijan Sobhian2, Nicolas Bertin1,2, Kavith...

In Alzheimer disease, increased b-secretase (BACE1) activity has been associated with neurodegeneration and accumulation of amyloid precursor protein (APP) products. Thus, inactivation of BACE1 could be important in the treatment of Alzheimer disease. In this study, we found that lowering BACE1 levels using lentiviral vectors expressing siRNAs targeting BACE1 reduced amyloid production and the ...

A low level of tissue oxygen (hypoxia) is a physiological feature of a wide range of diseases, from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydroxylase enzymes, which regulate the protein stability of hypoxia-inducible factor α (HIF-α) transcription factors. When stabilised, HIF-α binds with its cofactors to HIFresponsive elements (HREs) in the promoters of target ge...

a Department of Forestry, Instituto Superior de Agronomia, Tapada da Ajuda, 1349-017 Lisboa, Portugal. b Department of Mathematics, Instituto Superior de Agronomia, Tapada da Ajuda, 1349-017 Lisboa, Portugal, and Center for Logic and Computation, Instituto Superior Técnico, Lisboa, Portugal. c Remote Sensing Department, Instituto Nacional de Pesquisas Espaciais, Av. dos Astronautas, 1758, CEP 1...