Background Familial hypercholesterolemia (FH) is a disorder that is inherited by autosomal dominant pattern. The main cause of FH disease is the occurrence of mutations in low-density lipoprotein receptor (LDLR) gene sequence, as well as apolipoprotein B and proprotein convertase subtilisin/kexin type 9 genes, located in the next ranks, respectively. Materials and Methods Forty-five unrelated...

Molecular changes during aging have been studied to understand the mechanism of aging progress. Herein, changes in microRNA (miRNA) expression in the whole blood of mice were studied to systemically reverse aging and propose them as non-invasive biomarkers. Through next-generation sequencing analysis, we selected 27 differentially expressed miRNAs during aging. The most recognized function invo...

Cell culture from ovarian tissue of healthy female fingerlings Oreochromis niloticus was established with average weight of 20 to 30 gm/female. Three culture media were screened and tested: Leibowitz L-15), Minimum essential medium (MEM) and RPMI 1640 medium. Cells were maintained at 16, 27 or 30C for screening the favorable optimally incubation temperature. Culture medium was refreshed every 5...

Metastasis is the principal cause of cancer death and occurs through multiple, complex processes that involve the concerted action of many genes. A number of studies have indicated that the Fragile Histidine Triad (FHIT) gene product, FHIT, functions as a tumor suppressor in a variety of common human cancers. Although there are suggestions of a role for FHIT loss in progression of various cance...

Spasmodic dysmenorrhea is a recurring condition which disturbs the daily routine of females in abundance. It commonest gynaecological affects many women regardless age, race and region. one leading cause absenteeism adult with substantial economic loss, disrupt personal life significant public health problem as well. Also responsible for poor academic work performance. Mild pain common menstrua...