It has become clear that the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is central for promoting both tumor and tumor stroma and is therefore a major target for anticancer drug development. First- and second-generation rapalogs (prototypical mTOR inhibitors) have shown promise but, due to the complex nature of mTOR signaling, can result in counterprodu...

Information Systems (IS) and Technologies assume a wide variety of roles within companies, ranging from operational to strategic support of the company. This fact puts pressure on managers, who are required to manage these investments properly. This chapter presents a study conducted with several Chief Information Officers from large Iberian companies with the purpose of identifying and charact...

Mohammad­Reza Alam, Yuming Liu and Dick K. P. Yue Journal of Fluid Mechanics / Volume 689 / December 2011, pp 529 ­ 540 DOI: 10.1017/jfm.2011.448, Published online: 08 November 2011 Link to this article: http://journals.cambridge.org/abstract_S0022112011004484 How to cite this article: Mohammad­Reza Alam, Yuming Liu and Dick K. P. Yue (2011). Attenuation of short surface waves by the sea floor ...

Richmond, Keith Neu, Johnathan D. Tune, Mark W. Gorman, and Eric O. Feigl. Role of KATP 1 channels and adenosine in the control of coronary blood flow during exercise. J Appl Physiol 89: 529–536, 2000.—The present study was designed to examine the role of ATP-sensitive potassium (KATP 1 ) channels during exercise and to test the hypothesis that adenosine increases to compensate for the loss of ...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 739 6.5 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 790 6.9 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 842 7.4 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 872 7.7 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

MICHAEL DRMOTA, OMER GIMÉNEZ and MARC NOY Combinatorics, Probability and Computing / Volume 20 / Issue 04 / July 2011, pp 529 ­ 570 DOI: 10.1017/S0963548311000198, Published online: 31 May 2011 Link to this article: http://journals.cambridge.org/abstract_S0963548311000198 How to cite this article: MICHAEL DRMOTA, OMER GIMÉNEZ and MARC NOY (2011). The Maximum Degree of Series­ Parallel Graphs. C...

Atopic dermatitis (AD) is a chronic inflammatory skin disease with several key hallmarks, including elevated Th2 cytokines, interleukin (IL)-4 and IL-13; spongiosis; barrier deficits pruritus. The goal of this study was to characterize the immune cell populations present in circulation AD donors compared healthy controls. Plasma samples from had increased levels TARC (CCL17) IgE consistent acti...

Journal of Comparative NeurologyVolume 529, Issue 13 p. 3273-3273 ISSUE INFORMATION - TOCFree Access The Neurology, Table Content, Vol. No. 11, September 2021 First published: 09 July https://doi.org/10.1002/cne.25206AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check...

Journal of Comparative NeurologyVolume 529, Issue 8 p. 1721-1723 ISSUE INFORMATION - TOCFree Access The Neurology, Table Content, Vol. No. 8, June, 2021 First published: 29 March https://doi.org/10.1002/cne.25132AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box ...