The iron-sulfur protein putidaredoxin from Pseudomonas putida contains 106 amino acids arranged in a single peptide chain. The complete amino acid sequence has been determined. The molecular weight including 2 atoms each of iron and sulfur is 11,594. The molecule contains 6 cysteine residues. It is suggested that positions 39, 45, 48, and 85 (or 86) may be chelated to the iron in the iron sulfi...

Abstract Background Accurate prediction of mortality in heart failure (HF) patients is crucial for decision-making regarding HF therapies, but a strategy the elderly has not been established. In addition, although favorable effects comprehensive cardiac rehabilitation (CR) on clinical outcomes and functional status have demonstrated, goal CR during hospitalization reducing remains unclear. Aims...

Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...

Aalders JG 1627 Aas T 74 Abbou CC 1515 Abdulkarim B 2017 Abeliovich D 36 Adami H-O 678, 1317 Adams LM 1403 Adjei AA 484 Adjuvant Breast Cancer Project Belgium 1 Agelaki S 798 Aguggini S 1106 Agus V 1535 Ahern R 953 A’Hern R 1383 Aherne GW 446 Ahlner-Elmqvist M 1478 Ahmad SA 584 Ahmed A 1667 Aillet G 1831 Aine R 552 Akahira J 1731 Al-Mulla F 692, 1032 Alakhov VY 1987 Ali MS 661 Allen-Mersh TG 16...

Accelerated chemotherapy 1444 Acquired resistance 1064 ADCC 463 Adenocarcinomas 1023, 1153, 1371, 1781 Adenomatous polyposis coli 69, 98 Adjuvant chemotherapy 827, 1251 Adjuvant therapy 1437 Advanced breast cancer 141 Advanced gastrointestinal cancer 1265 Aetiology 1667 Ageing 930 Aggressive fibromatosis 98 AIDS 1298 Alcohol 46, 341, 678 Alcohol intake 1700 ALIMTA 649 Allelic imbalance 1201 Alp...

Sequence analysis of peptide deformylase of Mycobacterium tuberculosis revealed the presence of insertions (residues 74 to 85) and an unusually long carboxy-terminal end (residues 182 to 197). Our results with deletion mutants indicated the contribution of these regions in maintaining enzymatic stability. Furthermore, we showed that the region spanning the insertions was responsible for maintai...

objective: animal studies show that vaccination with epitope-based peptides results in protective immunity. however, immunodominance should be regarded as a major challenge in this area. considering the advantages of epitopic-vaccines against hepatitis c virus (hcv) infection, herein, we compared the occurrence of immunodominance following mice immunization with three different hcv epitopic-pep...

A new antibiotic sohbumycin, was isolated from the culture broth of Streptomyces sp. No. 82-85. It appeared to belong to the peptide lactone type of antibiotics from physico-chemical studies and has an empirical formula of C31H47N8O10Cl. In in vitro studies, the antibiotic was found to possess potent cytocidal activity against HeLa S3 cells and antimicrobial activities against Gram-positive bac...