Muscle weakness is the main characteristic of amyotrophic lateral sclerosis, which eventually leads to functional impairment and respiratory insufficiency. Progressive derives from a loss motor units active muscle fibres. Striated contraction depends on interaction between intracellular calcium protein troponin. Troponin made up three subunits—troponin C especially important for binding promoti...

OBJECTIVE To report on general anesthesia management in amyotrophic lateral sclerosis. CASE PRESENTATION AND INTERVENTION A 47-year-old man presented with fracture of the humerus. The patient was diagnosed with amyotrophic lateral sclerosis. General anesthesia was induced with propofol, rocuronium and remifentanil. After uneventful surgical repair, TOF (train-of-four) ratio reached >0.90 at t...

Amyotrophic lateral sclerosis (ALS) is a devastating paralytic disorder caused by motor neuron degeneration. A subgroup of familial cases arises from mutations in the gene encoding cytosolic superoxide dismutase (SOD1). This review considers insight now being gained into ALS pathogenesis from the study of mutant SOD1 protein and its possible mechanisms of adverse effect on nerve cells. Also dis...

Introduction and clinical pathology of Amyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis (ALS) also known as Lou Gehrig's disease is the generic name for progressive muscular atrophy and bulbar palsy. It refers to all disorders of the cortico spinal pathways which are characterized by progressive muscle weakness. After multiple sclerosis, ALS is the most common purely neurologic...

INTRODUCTION Amyotrophic lateral sclerosis is a neurodegenerative disease characterized clinically by motor symptoms including limb weakness, dysarthria, dysphagia, and respiratory compromise, and pathologically by inclusions of transactive response DNA-binding protein 43 kDa (TDP-43). Patients with amyotrophic lateral sclerosis also may demonstrate non-motor symptoms and signs of autonomic and...

The aim of the present study was to analyzed vowel and diphthong formant variation of a female patient diagnosed with amyotrophic lateral sclerosis (ALS) for 12 months using acoustic analysis. Monophthongs /a, i, u/ and diphthongs /h+ja+da/, /h+wi+da/, /h+ɰi+da/ were used for test. As the result of analysis, fundamental frequency and loudness declined with the progress of ALS characterized by d...