Background and Objective: Due to the importance of acute kidney injury associated in patients with sepsis and the impact of various factors on mortality and hospital stay of these patients, this study was conducted to investigate the clinical features and risk factors for acute kidney injury in patients with sepsis. In addition, we examined whether the severity of acute kidney injury affected c...

primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. this study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. we have evaluated the effect of caffeine, a non-sele...

CONTEXT Microvascular thrombosis is a critical event in severe acute pancreatitis. Human recombinant activated protein C (Xigris®, Eli Lilly, Indianapolis, IN, USA) modulates the interplay between pro-inflammatory and pro-coagulant pathways and maintains microvascular patency. However, the anticoagulant properties of Xigris® may precipitate bleeding from the inflamed pancreas. OBJECTIVE This ...

Abstract Background The plant Culcasia angolensis (Araceae) has diverse ethnomedicinal uses, including the management of rheumatic pain, healing cuts, dislocations, and bruises. Despite its potential therapeutic toxicity profile not been evaluated. This study assessed sub-acute effects leaves extract (CAE). phytochemical determination CAE was conducted as per standard protocols. median lethal d...

The purpose of this study is to evaluate the acute oral toxicity Turmeric based herbal product in sprague dawley rats. Acute refers those adverse effects occurring following administration a single dose substance, or multiple doses given within 24 hours. LD50 value, defined as statistically derived that, when administered an test, expected cause death 50% treated animals period, currently basis...

Acute myopia following use of some drugs is a relatively rare condition. Topiramate prescribed for seizure prophylaxis is one of these drugs. In this paper a case of acute transient myopia after taking topiramate is reported. The reported patient is a 28-year old woman who had no history of any eye disease. Following consumption of topiramate pill for one week, she had found blurred vision ...

STUDY OBJECTIVE The study objective was to determine whether intravenous contrast administration for computed tomography (CT) is independently associated with increased risk for acute kidney injury and adverse clinical outcomes. METHODS This single-center retrospective cohort analysis was performed in a large, urban, academic emergency department with an average census of 62,179 visits per ye...

background: recurrent herpes labialis (rhl) is one of most common infective vesiculoulcerative lesions. according to some studies administration of topical and/or systemic zinc compositions has been effective in treatment and prevention. this article aims to comparison of zinc level in healthy subjects and rhl patients in acute and convalescent phases. materials and methods: this was a retrospe...