A review on applicability of in silico methods for toxicity testing by calculation for regulatory purposes, their survey and background of QSAR (Quantitative Structure-Activity Relationships) analysis are presented.

The toxicity, haematological and erythrocyte membrane stabilizing effects of different parts of Kigelia africana were evaluated. The different parts namely bark, leaf and fruit were subjected to phytochemical tests and flavonoids, saponnins, phlobatannin and tannins were found. Sub-acute toxicity study showed no adverse effect on erythrocytic indices at the doses tested for 28 days, Kigelia afr...

Alpha-cypermethrin, which is a synthetic pyrethroid pesticide and potential toxic pollutant, contaminating aquatic ecosystems was investigated in the present study for acute toxicity. Nile tilapia (Oreochromis niloticus) adults were selected for the bioassay experiments. The experiments were repeated three times and the 96-h LC50 value was determined for the adults. The static test method of ac...

Generic water quality guidelines (WQGs) are developed by countries/regions as broad scale tools to assist with the protection of aquatic ecosystems from the impacts of toxicants. However, since generic WQGs cannot adequately account for the many environmental factors that may affect toxicity at a particular site, site-specific WQGs are often needed, especially for high environmental value ecosy...

Flow-through toxicity tests were conducted on common freshwater fishes: rainbow trout (Oncorhynchus mykiss), three-spined stickleback (Gasterosteus aculeatus), roach (Rutilus rutilus), perch (Perca fluviatilis) and dace (Leuciscus leuciscus), to estimate their sensitivity to acute toxicity of nickel. The 96-hour median lethal concentration (96-hour LC50) values obtained from the tests ranged fr...

Concurrent porewater (PW) and elutriate (ELU) toxicity testing using newly fertilized larvae of the bivalve Mytilus galloprovincialis was conducted as part of sediment quality triad (SQT) investigations for urban harbor locations. PW samples were consistently more toxic to bivalve larvae than the corresponding ELU sample, including samples collected from uncontaminated reference locations. Ammo...

Acute toxicity tests for the pesticides endosulfan and malathion on the larvae of Chironomus ramosus were conducted. Median Lethal Concentration (LC50) values of endosulfan were 0.55 x 10(-2), 0.16 x 10(-2), 0.089 x 10(-2) and 0.036 x 10(-2) ppb respectively, while those for malathion were 0.139 x 10(-2), 0.054 x 10(-2), 0.019 x 10(-2) and 0.0032 x 10(-2) ppb respectively, at 24, 48, 72 and 96 ...

Neutralact(R), the DSM brand name of a lactase enzyme preparation, obtained from a homologous rDNA strain of Kluyveromyces lactis, was subjected to a series of toxicological tests to document the safety for use as a processing aid in the dairy industry. The enzyme preparation was examined for subacute oral toxicity and mutagenic potential. As a result of these tests, no evidence of oral toxicit...

Cedrus atlantica (Endl.) Manetti ex Carrière is an endemic tree with spiritual value, and it was used since immemorial time in folk medicine. The present study aims to evaluate the anti-inflammatory (carrageenan-induced paw edema formalin tests) analgesic effects (hot plate acetic acid writhing of cedarwood essential oil, as well inspect any toxicity (acute toxicity), using several vivo assays....