We solve the stochastic equations for a cluster of parallel bonds with shared constant loading, rebinding, and the completely dissociated state as an absorbing boundary. In the small force regime, cluster lifetime grows only logarithmically with bond number for weak rebinding, but exponentially for strong rebinding. Therefore rebinding is essential to ensure physiological lifetimes. The number ...

Adhesion level for the proper running of rail wheelset on track has remained a significant problem for researchers in detecting slippage to avoid accidents. In this paper, the slippage of rail wheels has been observed applying forward and lateral motions to slip velocity and torsion motion. The longitudinal and lateral forces behavior is watched with respect to traction force to note correlatio...

Abstract. This paper discusses an improvement for an autonomous robot’s magnetic climbing system necessary to perform the inspection of metal plates and weld beads in internal/external LPG storage sphere’s surfaces. This task typically covers up to 360◦ in the roll-pitch-yaw angles navigation with respect to the Earth‘s surface plan. Also, the storage spheres’ metal surfaces present non-modeled...

Cell-cell contacts in tissues are continuously subject to mechanical forces due to homeostatic pressure and active cytoskeleton dynamics. In the process of cellular adhesion, the molecular pathways are well characterized but the role of mechanics is less well understood. To isolate the role of pressure we present a dense packing of functionalized emulsion droplets in which surface interactions ...

Gecko and many insects have adopted nanoscale fibrillar structures on their feet as adhesion devices. Here, we consider adhesion between a single fiber and a substrate by van der Waals or electrostatic interactions. For a given contact area A, the theoretical pull-off force of the fiber is sigma(th)A where sigma(th) is the theoretical strength of adhesion. We show that it is possible to design ...

Homophilic binding of E-cadherins through their ectodomains is fundamental to epithelial cell-cell adhesion. Despite this, E-cadherin ectodomains have evolved differently in the vertebrate and hexapod lineages. Of the five rod-like, tandemly aligned extracellular cadherin domains (ECs) of vertebrate E-cadherin, the tip EC plays a pivotal role in binding interactions. Comparatively, the N-termin...

Recent advances in atomic force microscopy, biomembrane force probe experiments, and optical tweezers allow one to measure the response of single molecules to mechanical stress with high precision. Such experiments, due to limited spatial resolution, typically access only one single force value in a continuous force profile that characterizes the molecular response along a reaction coordinate. ...

Bacterial adhesion and the subsequent formation of biofilm are major concerns in biotechnology and medicine. The initial step in bacterial adhesion is the interaction of cells with a surface, a process governed by long-range forces, primarily van der Waals and electrostatic interactions. The precise manner in which the force of interaction is affected by cell surface components and by the physi...

Many geckos use adhesive toe pads on the bottom of their digits to attach to surfaces with remarkable strength. Although gecko adhesion has been studied for hundreds of years, gaps exist in our understanding at the whole-animal level. It remains unclear whether the strength and maintenance of adhesion are determined by the animal or are passively intrinsic to the system. Here we show, for the f...

This paper explores the nano-scratch technique for measuring the adhesion strength of a single osteoblast cell on a hydroxyapatite (HA) surface reinforced with carbon nanotubes (CNTs). This technique efficiently separates out the contribution of the environment (culture medium and substrate) from the measured adhesion force of the cell, which is a major limitation of the existing techniques. Na...