نتایج جستجو برای: animal study
تعداد نتایج: 4104704 فیلتر نتایج به سال:
Cafestol and kahweol, coffee lipids present in unfiltered coffee brews, potently increase LDL-cholesterol concentration in human subjects. We searched for an animal species in which cafestol similarly increases LDL-cholesterol. Such an animal model could be used subsequently as a model to study the mechanism of action of cafestol and kahweol. Cafestol and kahweol increased serum lipids in Afric...
Numerous animal studies have reported that garlic can protect against atherosclerosis. However, a comparable number of studies do not support this observation. This contradiction may result from differences in study design, use of different animal models, and use of different garlic formulations and preparations. Here, we investigated the effect of the chemically well-characterized and producti...
Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis using animal models, yet few of these compounds have replicated these beneficial effects in clinical trials. Given the challenges associated with performing clinical trials in patients with idiopathic pulmonary fibrosis (IPF), it is imperative that preclinical data packages be robust in their analyses and inter...
INTRODUCTION A large number of studies are currently focused on diagnosis, prevention, and treatment of complex disorders. Animal studies are generally utilized as basic models for in-vivo studies and support subsequent clinical trials. Although animal models have so far been fruitful in understanding the mechanism of several diseases and testing the likely prevention and treatment strategies; ...
Current ovarian cancer treatment involves chemotherapy that has serious limitations, such as rapid clearance, unfavorable biodistribution and severe side effects. To overcome these limitations, drug delivery systems (DDS) have been developed to encapsulate chemotherapeutics for delivery to tumor cells. However, no systematic assessment of the efficacy of chemotherapy by DDS compared to free che...
The clinical use of hematopoietic growth factors (HGFs) is built on nearly 20 years of in vitro studies followed by preclinical animal studies. These laboratory and animal studies, undertaken before first use in humans, provided the basis for expectations of what the biologic effects in humans would be. Reflecting the available technologies, the initial animal studies primarily evaluated the in...
abstract the purpose of this study was to find out the effect of applying the principles of group-dynamic assessment (g-da) on learning of conditional structures in english by iranian efl learners at the intermediate level, which according to the formal educational system in iran, includes students who are in their second year of studying in high schools of koohdasht city. this study was a qua...
Prior work using animal models to study the effects of obesogenic diets on food motivation have generated inconsistent results, with some reporting increases and others reporting decreases in responding on food-reinforced tasks. Here, we identified two specific variables that may account for these discrepant outcomes - the length of time on the obesigenic diet and the familiarity of the food re...
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