This study was conducted to investigate the possible involvement of the histaminergic system in themediation of ghrelin-induced feeding behavior in broiler chickens. In the trial 1, the effect ofintracerebroventricular (ICV) injection of ghrelin on feed intake was examined in 3-h feed-deprived broilerchickens. In the trials 2 and 3, the chickens were received ICV chlorpheniramine (an H1 recepto...

We add to growing research on how rightwing populism undermines democracy by identifying populist strategy works in parliamentary democracy. examine the fate of 2013 Estrela Report European Parliament, a legislative body which used be characterised high degree respect and deliberation. This became an unprecedented object ultra-conservative mobilisation, shocking MEPs unravelling consensus-drive...

Moringa stenopetala (Baker f.) Cufod., is an endemic species growing in the south of Ethiopia. M. often consumed as food and used traditional medicine it has also been traditionally for relieving pain This study aimed to investigate antinociceptive effect mechanisms action leaves methanol extract mice. The per-oral doses 50, 100, 200 mg/kg were tested by using hot-plate, tail-immersion, writhin...

Purpose: Abnormal Sonic Hedgehog signaling Pathway (Shh) activation is crucial for development of cancer stem cells, neoplastic growth and epithelial-mesenchymal transition processes in adulthood. Activation pathway may induces the changes cilia found cell membrane, iniciates Gli1 transcription factor that translocated to nucleus finally, target genes are transcribed. In this study, invastigati...

Beside acetylcholinesterase, butyrylcholinesterase could be considered as a putative target of interest for the symptomatic treatment Alzheimer’s disease (AD). As result complexity AD, no molecule has been approved since 2002. Idalopirdine, 5-HT6 receptors antagonist, did not show its effectiveness in clinical trial despite evaluation adjunct to cholinesterase inhibitors. Pleiotropic molecules,...

The failure of endothelin antagonists to show benefit in heart failure cannot be understood until all the clinical trials are fully published.

antiemetics are given to cancer patients prior to their chemotherapy sessions to protect them from nausea and vomiting induced by chemotherapy. the responsible health care team member will choose the type of antiemetic required to prevent the patient from developing nausea and vomiting according to the chemotherapy ematogenicity level. current guidelines recommend using a single antiemetic agen...

Diabetic neuropathic pain, an important micro vascular complication in diabetes mellitus, has been recognized as one of the most difficult types of pain to treat. Lack of understanding of etiology involved, inadequate relief, development of tolerance and potential toxicity of classical anti-nociceptive agents warrants the investigation of newer agents to relieve this pain. The aim of the presen...