Breast cancer is the most common cancer type among women all over the world. Chemotherapy is the use of anticancer medicines for treating cancer but it has many side effects and cells may become resistant to these chemical medicines. Therefore, finding new compounds of natural origin could be a promising solution to this problem. The aim of the current study was to evaluate anticancer activity ...

A growing area of research is focused on cancer therapy, and new therapeutic approaches are welcomed. Mesenchymal stem cell (MSC)-based gene therapy is a promising strategy in oncology. Intrinsic tropism and migration to tumor microenvironment with off lights are attractive features of this type of cell carrier. In this way, suicide genes have also found a good platform for better performance a...

objective: immunotoxins (its) have been developed for the treatment of cancer, and comprise of antibodies linked to toxins. also vascular endothelial growth factor (vegf) plays a key role in tumor angiogenesis, and the blockade of vegf receptor-2 (vegfr2) inhibits angiogenesis and tumor growth. the aim of this study was to produce anti-vegfr2/rpe (pseudomonas exotoxin) 38 it to test its cytotox...

Without using any solvents, a green and highly efficient protocol for the preparation of ferrocenyl chalcones has been achieved by grinding between acetylferrocene aldehyde. In addition, their in vitro antiproliferative activity against two breast cancer cell lines MCF-7 (estrogen receptor-positive) MDA-MB-231 (triple negative cancer, TNBC) was also evaluated. Most them exhibited excellent cell...

cinnamon is the bark the cinnamomi cassia that exhibits many medical properties such as anti-cancer effect and anti-diabetic effect. moreover, because of its antioxidant activity; it can be used in food industries. many studies have already reported biological and chemical properties of the cinnamon extracted essential oil such as their antimicrobial, antifungal, antimosquito, free radical scav...

Three near-infrared (NIR-I) optical theranostic systems were synthesized, characterized and studied in vitro vivo. These original homo-bimetallic gold(I)-based aza-BODIPY complexes proved to be trackable through imaging cells mice. They display anti-proliferative properties micromolar range against human murine cancer cell lines (4T1, MDA-MB-231, CT26, SW480). Moreover, the injection of most pr...

background: malignant melanoma is a highly aggressive malignant melanocytic neoplasm which resists against the most conventional therapies. sea cucumber as one of marine organisms contains bioactive compounds such as polysaccharide, terpenoid and other metabolites which have anti-cancer, anti-tumor, anti-inflammatory and antioxidant properties. the present study was designed to investigate the ...

Prostate cancer is a devastating disease for which current therapies are inadequate. Various lines of evidences have suggested the 5-lipoxygenase (5-LOX) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of Prostate cancer. Thus, search for new anti-cancer drugs targeting 5-LOX and leukotriene is very essential and important. The objective of the pre...

Cancer is not just one disease, but a large group of almost one hundred diseases. Its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to migrate from the original site and spread to distant sites. If the spread is not controlled, cancer can result in death. There has been continuous progress in the development of therapy for cancer....