Neuroendocrine tumors can arise from any portion of the gastrointestinal tract including the colon and rectum. In the scope of all colon and rectal malignancies, they are a rare cause of colorectal carcinoma. Relating to their pluripotent neuroendocrine cellular origins these carcinomas can produce a variety of biologically active peptides with several resultant paraneoplastic syndromes. One of...

Olfactory neuroblastoma (ONB) is an uncommon neuroendocrine sinonasal cancer associated by many authors to ectopic production of several biologically active substances. We report a case of a 31-year-old male patient who presented with idiopathic syndrome of inappropriate secretion of antidiuretic hormone (SIADH). During diagnostic work-up, a CT scan of the head was performed and an ethmoidal ON...

The plasma membrane of the bovine renal collecting duct epithelial cell has been resolved into its apical (luminal) and basal-lateral (contraluminal) components by free flow electrophoresis. The contraluminal, but not the luminal, membrane was found to contain antidiuretic hormone-sensitive adenylate cyclase. The luminal membrane was found to contain a cyclic 3':5'-adenosine monophosphate-sensi...

The steroids of the adrenal cortex assist in, and are necessary for, normal excretion of water and electrolyte (1). In general, these steroids tend to cause water excretion and salt retention, the relative amounts of these responses being dependent upon the structure of the steroid. The hormones of the posterior pituitary gland, on the other hand, cause water retention and, usually, sodium and ...

MILLER, M. & MOSES, A.M. (1969) Chlorpropamide induced release of antidiuretic hormone in patients with diabetes insipidus (abstracts). Clinical Research, 17, 290. MILLER, M. & MOSES, A.M. (1970a) Potentiation of vasopressin action by chlorpropamide in vivo. Endocrinology, 86, 1024. MILLER, M. & MOSES, A.M. (1970b) Mechanism of chlorpropamide in diabetes insipidus. Journal of Clinical Endocrino...

Carbamazepine (CBZ) has been reported to have an antidiuretic action, though it is not known how it produces this effect. This is a well recognized complication of CBZ therapy in adults. However this syndrome has been rarely observed in childhood. We present an epileptic child with fluid overload due to CBZ treatment who was referred with chest pain and cardiomegaly. Our patient developed fluid...

A B S T R A C T The effect of beta adrenergic stimulation on renal-diluting capacity was examined in the dog. Beta adrenergic stimulation with intravenous isoproterenol significantly increased urinary osmolality (Uo.m) and decreased free water clearance (CH:}O), and these effects were rapidly reversible with cessation of the infusion. This antidiuretic effect of systemic beta adrenergic stimula...

The diuretic response to intravenous infusions of 5 per cent glucose in water and the antidiuretic response to intravenous injections of nicotine salicylate and aqueous Pitressin, during maximal water diuresis, were studied in normal subjects and patients in congestive failure of varying severity. Patients in moderately severe congestive failure exhibited normal diuretic responses during the pe...