Objective Apigenin is a plant-derived compound belong to the flavonoids category and has the protective effects on different cells. The aim was to evaluate the effect of apigenin on the number of viable and apoptotic blastomeres, the zona pellucida (ZP) thickness and the hatching rate of preimplantation mouse embryos exposed to H2O2 and actinomycin D. MaterialsAndMethods 420 two-cell embryos we...

Extracellular vesicles (EVs) are important players in the communication between different kinds of cells by delivering their content, consisting types RNA, proteins, bioactive lipids, or signaling nucleotides, into target cells. Several EVs distinguished: (1) exosomes with sizes from 30 to 150 nm originate endosomal pathway and form intracellular multivesicular bodies (MVBs), which fuse plasma ...

  Background and Objective: Garlic has been known worldwide as a dietary constituent with many pharmacological effects. The present in vitro study was designed to investigate the putative anticancer effect of garlic extract on cancer cells, and if this effect was through apoptosis induction. Material and Methods:  Human colon adenocarcinoma cells HT29 were treated with different doses (1, 5 a...

Background: In reproductive biology, testicular organoids can be used to treat infertility and study development spermatogonial stem cells (SSCs) differentiation. Generating organoid from primary is challenging. this study, were created using human evaluated the apoptotic gene expression hormone secretion profiles of organoids. Materials Methods: Primary isolated 2-step enzymatic digestion thre...

Interaction of macrophages with apoptotic cells involves multiple steps including recognition, tethering, phagocytosis, and anti-inflammatory macrophage responses. Defective apoptotic cell clearance is associated with pathogenesis of autoimmune disease. CD14 is a surface receptor that functions in vitro in the removal of apoptotic cells by human and murine macrophages, but its mechanism of acti...

Berberine has been used for the adjuvant treatment of type 2 diabetes mellitus, hyperlipidemia (high levels fats), and hypertension blood pressure). Also, it different effects on diarrhea, inflammation, cancer. Berberine, is a profoundly common compound in Berberis species. Although cretica one species, unknown whether anti-diabetic yet. synergistic various compounds together with berberin or s...

Abstract Objective: To investigate the involvement of HOX transcript antisense RNA (HOTAIR) in injury renal tubular epithelial cells induced by high glucose. Results: In glucose‐induced HK‐2 cells, expression HOTAIR was upregulated, resulting suppressed cell proliferation. Meanwhile, upregulates pro‐apoptotic proteins Bax and cleaved caspase‐3, while downregulating anti‐apoptotic protein Bcl‐2....

Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin CO [...]