Subcutaneous adipose tissue blood flow is finely regulated, and tuned with fat metabolism; little is known about visceral fat, which is less accessible in humans. In estimating blood flow with positron emission tomography (PET) and oxygen-15-labelled water ([ 15 O]H2O), the input function is obtained invasively from arterial blood samples. The aim of the current study was to validate a non-inva...

C Cl li in ni ic ca al l s si ig gn ni if fi ic ca an nc ce e o of f p pu ul lm mo on na ar ry y a ar rt te er ri ia al l i in np pu ut t i im mp pe ed da an nc ce e Pulmonary arterial input impedance excites the attention of few clinicians, but there are compelling reasons why they should be more interested in this subject. Physicians are well-versed in the intricacies of pulmonary vascular re...

Adoption of standard input function (SIF) has been proposed for kinetic analysis of receptor binding potential (BP), instead of invasive frequent arterial samplings. The purpose of this study was to assess the SIF method in quantitative analysis of [123I]iomazenil (IMZ), a central benzodiazepine antagonist, for SPECT. SPECT studies were performed on 10 patients with cerebrovascular disease or A...

UNLABELLED (11)C-meta-hydroxyephedrine ((11)C-HED) kinetics in the myocardium can be quantified using a single-tissue-compartment model together with a metabolite-corrected arterial blood sampler input function (BSIF). The need for arterial blood sampling, however, limits clinical applicability. The purpose of this study was to investigate the feasibility of replacing arterial sampling with ima...

UNLABELLED As clinical PET becomes increasingly available, quantitative methods that are feasible in busy clinical settings are becoming necessary. We investigated the use of intracranial blood pools as sources of an input function for quantitative PET. METHODS We studied 25 patients after the intravenous injection of [18F]6-fluoro-L-m-tyrosine and compared sampled blood time-activity curves ...

J. J. Jain, W. E. Reddick Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States PURPOSE Absolute quantification of cerebral blood flow (CBF) and volume (CBV) using dynamic-susceptibility contrast MRI relies on deconvolution of the arterial input function (AIF) commonly estimated from signal changes in a major artery. However, the presence of bolus delay and di...

BACKGROUND CT perfusion (CTP) is an important diagnostic tool for the imaging of cerebral hemodynamics. To obtain quantitative values of cerebral blood volume (CBV), blood flow (CBF), and mean transit time (MTT), measurement of the arterial input function (AIF) is required. To correct for partial volume effects (PVEs), it is common to normalize the AIF with respect to the venous output function...

Automated Arterial Input Function Detection in Ascending Aorta for Breast DCE-MRI Venkata Veerendranadh Chebrolu, Dattesh D Shanbhag, Sheshadri Thiruvenkadam, Sandeep Kaushik, Uday Patil, Patrice Hervo, Sandeep N Gupta, and Rakesh Mullick Medical Image Analysis Lab, GE Global Research, Bangalore, Karnataka, India, GE Healthcare, Buc, France, Biomedical Image Processing Lab, GE Global Research, ...