an electroorganic reaction for the synthesis of 7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1h-pyrano[2, 3-d] pyrimidine-6-carbonitrile and ethyl-7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1h-pyrano[2, 3-d] pyrimidine-6-carboxylate derivatives are described, using an electrogenerated base of the anion of malonitrile or ethylcyanoacetate. this one-pot, three-component condensation of an a...

Homogeneous hydrogenation of barbituric acid derivatives with parahydrogen yields a substantial increase of the (1)H NMR signals of the reaction products. These physiologically relevant compounds were hydrogenated at both ambient and elevated temperatures and pressures using a standard cationic rhodium catalyst. The resulting nonthermal nuclear spin polarization (hyperpolarization) is limited b...

The molecular complexes between barbituric acid (BU) and chloranilic (ChA) over graphitic nitride (g-C3N4) are investigated. the nanocomposite were investigated both in solid state methanol. corresponding using FTIR, TGA, UV-Vis spectroscopy. structures explored DFT calculations wB97XD/ def2-TZVP basis set. revealed formation of hydrogen-bonded complexes, which initiate proton transfer from ChA...

The intermolecular hydrogen bonding of barbiturates assists in the supramolecular aggregation and a hypsochromic shift is shown protic solvents.

The crystal structure of barbituric acid dihydrate (C4H4N2O3*2H2O) has twice been reported as orthorhombic, space group Pnma, with all atoms (except for CH(2) H atoms) lying on the mirror plane [Al-Karaghouli et al. (1977). Acta Cryst. B33, 1655-1660; Jeffrey et al. (1961). Acta Cryst. 14, 881-887]. The present study has found that at low temperatures, below 200 K, the crystal structure is no l...

ACKNOWLEDGEMENTS First I would like to thank to my research advisor, Branko Jursic, for his help and advice. When I came to University of New Orleans, I did not know anything about organic chemistry. I still do not know much but Branko showed me the beauty of this field of chemistry and for this I will always be grateful. their scientific support and friendship. It has been a real pleasure to w...

Urease enzyme (EC 3.5.1.5) has been determined as a virulence factor in pathogenic microorganisms that are accountable for the development of different diseases in humans and animals. In continuance of our earlier study on the helicobacter pylori urease inhibition by barbituric acid derivatives, 3D-QSAR (three dimensional quantitative structural activity relationship) advance studies were perfo...