A task set may need to be inhibited to facilitate the switch to another task. This event-related potential (ERP) study determined (1) whether backward inhibition (BI) is exerted preferentially in high interference environments, and (2) whether ERPs locked to critical time points reflect BI during cue preparation and/or response stages. High interference (HI) and low interference (LI) were creat...

Bee venom contains a variety of peptides and enzymes, including serine proteases. While the presence of serine proteases in bee venom has been demonstrated, the role of these proteins in bee venom has not been elucidated. Furthermore, there is currently no information available regarding the melanization response or the fibrin(ogen)olytic activity of bee venom serine protease, and the molecular...

Business Intelligence and Analytics (BI&A) is an important topic of IS research with significant implications for practitioners. However, while substantial research exists related to BI&A, it often fails to bridge the gap between normative specifications on BI&A use and improved business outcomes such as the development of competitive advantage. Building on the dynamic capabilities perspective,...

The kinetic mechanism of the rod outer segment (ROS) isoprenylated protein methyltransferase was investigated. This S-adenosyl-L-methionine (AdoMet)-linked enzyme transfers methyl groups to carboxyl-terminal isoprenylated cysteine residues of proteins, generating methyl esters. The enzyme also processes simple substrates such as N-acetyl-S-farnesyl-L-cysteine (L-AFC). Initial studies showed tha...

In humanitarian relief operations (HRO), due to the excessive number of relief organizations, multiple organizational coordination is a demanding and complicated task. Considering such a problem, this paper proposes a two-phase mechanism to coordinate multiple heterogeneous relief organizations in a decentralized HRO logistics network. To address such a problem, first a bi-level mixed integer l...

Bacterial abortive infection (Abi) systems are 'altruistic' cell death systems that are activated by phage infection and limit viral replication, thereby providing protection to the bacterial population. Here, we have used a novel approach of screening Abi systems as a tool to identify and characterize toxin-antitoxin (TA)-acting Abi systems. We show that AbiE systems are encoded by bicistronic...

A new method for the determination of the spatial distribution of metal surface area within bimodal micro-/meso-porous solids has been developed. This novel technique involves incorporating a nonane pre-adsorption stage between two successive chemisorption experiments. This method has been used to probe the distribution of platinum amongst the micropores and mesopores of a range of bi-functiona...

Phytoene desaturase (PDS) is an essential plant carotenoid biosynthetic enzyme and a prominent target of certain inhibitors, such as norflurazon, acting as bleaching herbicides. PDS catalyzes the introduction of two double bonds into 15-cis-phytoene, yielding 9,15,9'-tri-cis-ζ-carotene via the intermediate 9,15-di-cis-phytofluene. We present the necessary data to scrutinize functional implicati...

BACKGROUND Current therapies to treat cancer, although successful for some patients, have significant side-effects and a high number of patients have disease that is either non-responsive or which develops resistance. Our goal was to design a small peptide that possesses similar functions to an antibody drug conjugate with regard to targeting and killing cancer cells, but that overcomes size re...

BACKGROUND We hypothesized that the American Heart Association's metric of ideal cardiovascular health (CVH) predicts improved long-term functional status after adjusting for incident stroke and myocardial infarction. METHODS AND RESULTS In the prospective, multiethnic Northern Manhattan Study, stroke-free individuals in northern Manhattan aged ≥40 years had annual assessments of the primary ...