Anthracycline antibiotics are widely used in cancer chemotherapy. Doxorubicin and Idarubicin, topoisomerase-targeting anthracyclines, were examined for their effect on chromosomal aberration and micronucleus induction in cultured human lymphocytes employing lymphocyte transformation test and cytokinesis-blocked micronucleus (CBMN) assay. A statistically significant dose-dependent increase in mi...

Primary effusion lymphoma (PEL) is an unusual and rare type of non-Hodgkin's lymphoma characterized by lymphomatous effusion of pleural, pericardial or peritoneal cavities without lymphadenopathy or organomegaly. It is associated with human herpes virus-8 (HHV-8) and occurs most often in immunodeficient patients. We present a case of PEL in a 69-year-old male presenting with pleural effusion an...

INTRODUCTION Dedifferentiated chondrosarcoma (DDCS) is a rare and malignant form of primary bone tumor refractive to chemotherapy and radiotherapy. It accounts for 1-2% of all primary bone tumors. Surgical resection, limb-salvage surgeries and amputation remain the mainstay of treatment. The prognosis of dedifferentiated chondrosarcoma is poor. CASE REPORT We report a case of a 51-year-old ma...

Intrafetal insulin-like growth factor (IGF)-I promotes cardiac hypertrophy in the late-gestation fetal sheep; whether these effects are sustained is unknown. IGF-I was infused for 4 days at 80 microg/h from 121 to 125 days of gestation, and its effects at 128 days, 3 days after the infusion stopped, were determined by comparison with untreated fetal sheep. After IGF-I treatment, fetal weights w...

Background: Cervical samples of patients with human papillomavirus (HPV) infections show positive results in HPV DNA testing. infection can alter cervical squamous epithelial cells (CSECs) to be abnormal. Epigenetically, CSECs that change abnormal are affected by Fas-promoter-670 gene polymorphism. High-risk (hr-HPV) infected other microbes, for example, Candida species (Candida sp.). The prese...

ABSTRACT: Poisoning by Trema micrantha commonly causes hepatocellular necrosis in cattle, sheep, and goats edema cerebral hemorrhage horses. This plant can cause toxic pneumopathy there is only one report of the natural form experimental State Rio Grande do Sul. study aimed to an outbreak respiratory poisoning T. sheep. Six sheep developed clinical signs after consumption four them died two rec...