The (10)B enriched form of Na(2)B(12)H(11)SH (BSH) is used in a binary cancer radiation treatment, known as boron neutron capture therapy (BNCT). The BSH anion can also form a dimer, [B(24)H(22)S(2)](4-) (BSSB), previously used in animal model studies. It is demonstrated here that the retention of BSSB in mouse M2R melanoma and rat C6 glioma cells is significantly longer than that of the monome...

BACKGROUND In boron neutron capture therapy, blood boron concentration is the key factor to calculate radiation dose, however, blood sampling is difficult during neutron irradiation. MATERIALS AND METHODS The prediction of blood boron concentrations for BNCT treatment planning has been prospectively investigated using patient data obtained at first craniotomy after the infusion of a low dose ...

Accelerator-based BNCT (Boron Neutron Capture Therapy) facilities are being studied, developed and constructed at many laboratories and hospitals, especially in Japan. In order to provide sufficient neutron flux in the epi-thermal energy region (0.5 ~ 10 keV), an intense proton beam accelerated with a cyclotron, linear accelerator (linac) or DC accelerator up to 2.5 ~ 30 MeV is directed to lith...

In the framework of the Italian BNCT research program, the low-power (5 kW), fast-flux, TAPIRO research reactor, located at the ENEA Casaccia Centre near Rome, is foreseen to be implemented as the national facility devoted to supply an epithermal neutron beam required for malignant brain tumor treatment[1]. The feasibility to provide both thermal and epithermal suitable neutron beams in the mai...

Boron neutron capture therapy (BNCT) is a tumor selective therapy, the effectiveness of which depends on sufficient 10B delivery to and accumulation in tumors. In this study, we used self-assembling A6K peptide nanotubes as boron carriers prepared new agents by simple mixing BSH. BSH has been treat malignant glioma patients clinical trials its drug safety availability have confirmed; however, c...

New multifunctional theranostic vectors allow the expansion of cancer therapeutic approaches toward scarcely investigated fields. One example is combination boron neutron capture therapy (BNCT) and X-ray radiotherapy (XRT) for treating normal XRT-resistant hypoxic tumor regions reduce recurrence. Of great relevance BNCT also support viable, rapid, safe, reliable techniques localization quantifi...