background: breast cancer is the most common malignancy among women. it is estimated that 1 in 10 women worldwide is affected by breast cancer during their lifetime. in 5 to 10% of breast cancer patients, the disease results from a hereditary predisposition, which can be attributable to mutations in either of two tumor suppressor genes, brca1 and brca2 to a large extent. brca2 6174delt mutation...

Background: The heterogeneous breast cancer is the most common cause of cancer-related mortality. Obesity defined by BMI is known as a major risk factor for breast cancer. Objective: The purpose of this study was to explore the role of obesity related-polymorphisms rs9939609 FTO and rs17782313 MC4R in breast cancer development. Materials and Methods: We obtained matched peripheral blood, serum ...

background: breast cancer is the most common type of cancer among women all over the world and breast cancer is a disease where quality of life (qol) has become a part of evaluation criteria for cancer therapy. the objective of this study was to evaluate the quality of life (qol) in breast cancer patients and its association with other factors. eortc qlq c30/+br23 (european organization for res...

breast reconstruction (br) surgery is not common for the treatment of breast cancer in low- and middle-income countries, including iran. we evaluated the quality of life (qol) in iranian breast cancer patients who underwent br at the cancer institute of iran. we compared patients who had br with breast cancer patients who had a radical mastectomy as the control group, matched for age, and time ...

Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered fr...

background& aims: the mortality rate for breast cancer is directly related to the stage of disease at diagnosis. the present study aimed to determine the influencing factors on knowledge, attitudes, and practices of women regarding breast cancer and its screening methods.material & methods: in a cross- sectional study, evaluated 383 women referring health centers of ilam. sampling was d...

Introduction: Gail model is one of the most important models for the evaluation of breast cancer risk between US white females. According to genetic diversity, there is a possibility of affecting the efficiency of the Gail model in risk assessment of breast cancer among Iranian populations. In this study, the Gail model efficiency in specifying the risk of breast cancer in Iranian population wa...

Introduction: Gail model is one of the most important models for the evaluation of breast cancer risk between US white females. According to genetic diversity, there is a possibility of affecting the efficiency of the Gail model in risk assessment of breast cancer among Iranian populations. In this study, the Gail model efficiency in specifying the risk of breast cancer in Iranian population wa...

background: interleukin-19, a member of the interleukin-10 family of cytokines, contributes to breast cancer pathogenesis. high interleukin-19 expression in breast tumor tissues is associated with poor clinical outcome. this study aimed to assess the changes in serum level of interleukin-19 in breast cancer patients in comparison with normal women and its association with the clinicopathologica...