Background: The excessive prescription of benzodiazepines (BZD) has long been considered a worldwide public health issue. Despite the existence large body literature regarding interventions to change BZD patterns, most fail report significant or long-term effects. Objective: To study effect implementation Digital Behaviour Change Intervention (DBCI) online platform – named ePrimaPrescribe on pa...

BACKGROUND Benzodiazepines (BZDs) have a sedative and hypnotic effect upon people. Short term use can be beneficial but long term BZD use is common, with several risks in addition to the potential for dependence in both opiate and non-opiate dependent patients. OBJECTIVES To evaluate the effectiveness of psychosocial interventions for treating BZD harmful use, abuse or dependence compared to ...

Seizure aggravation by antiepileptic drugs (AEDs) is increasingly recognized as a common problem, particularly in idiopathic generalized epilepsy (IGE). Benzodiazepines (BZDs) are one type of the main AEDs, especially in the treatment of status epilepticus. Paradoxical worsening of seizures associated with BZD is uncommon and most reports are among pediatric patients [1–3]. We report the case o...

Benzodiazepines (BZDs) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. However, they have some undesired effects including memory problems. In continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. Previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...

BACKGROUND It is difficult to assess the effectiveness of treatments in lowering suicide incidence. METHODS To ascertain the impact of antidepressants (AD) on suicidal behavior, we compared the psychopharmacological treatment taken in the previous 3 months by cases who had made or not a suicide attempt (SA) just before their admission to a hospital. RESULTS In comparison with not SA cases, ...

Las benzodiacepinas (BZD) son medicamentos esenciales en el tratamiento de diferentes problemas salud: En Petitorio Nacional Medicamentos nuestro país, figuran cinco ellas autorizadas para administración oral o parenteral. Al inicio su uso la década 1960, fueron prescritas forma amplia e irrestricta; desarrollo posterior fenómenos tolerancia y abstinencia desatados por prolongado restringió ené...

In Diagnostic and Statistical Manual (DSM)-5, catatonia is defined by the presence of three or more of 12 psychomotor disturbances, which may be associated with mental disorder or medical condition (Tandon et al. 2013). Catatonia could be treated with benzodiazepine (BZD) or electroconvulsive therapy (ECT) (Lin & Huang 2013, Huang et al. 2013, Raveendranathan et al. 2012). Parkinson's disease (...

Objectives: The objectives of this preliminary study were to identify a cohort of patients receiving outpatient prescriptions for a class of medications, benzodiazepines, that are known to increase the risk of adverse events, and to analyze the temporal association between outpatient benzodiazepine usage and inpatient and outpatient injury-related health care encounters for this cohort. Methods...

The evidence for the impact of benzodiazepine (BZD) use on infection or clinical outcomes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited. We evaluated association BZD with SARS-CoV-2 and disease 2019 (COVID-19) using a nationwide COVID-19 database from South Korea. This cohort study was performed Health Insurance Review Assessment Service Korea, positivity investigated ...