نتایج جستجو برای: canine model
تعداد نتایج: 2134006 فیلتر نتایج به سال:
اگرکیفیت معلم کلاس برای بهبودیادگیری دانش آموزحیاتی است،پس کیفیت اساتیددانشجو-معلمان، یابه عبارتی معلمین معلمان نیزبرای پیشرفت آموزش بسیارمهم واساسی است.ناگفته پیداست که یک سیستم مناسب آموزش معلمان ،معلمین با کیفیتی را تربیت خواهدکرد.که این کار منجربه داشتن مدارس خوب، ودرنتیجه نیروی کارماهرتروشهروندبهتربرای جامعه خواهدشد. اساتیددانشجو-معلمان نقشی بسیارمهم را در سیستم اموزش معلمان درسراسرجهان ای...
Understanding the evolution of proliferative breast disease such as atypical hyperplasia and carcinoma in situ is essential for clinical management of women diagnosed with these lesions. Therefore, an animal model that faithfully represents human breast disease in every aspect from spontaneity of dysplasia onset, histopathologic features, and genetics to clinical outcome is needed. Previously, ...
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model organism for breast cancer research. In order to obtain an insight into underlying signaling mechanisms during canine mammary tumorigenesis, in this study we assessed the incidence and the mechanism of canonical Wnt activation in a panel of 12 canine mammary tumor cell lines. We show that a subse...
BACKGROUND Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one of the catalytic subunits of Polycomb repressive complex 2, a crucial epigenetic regulator. EZH2 has a master regulatory function in such processes as cell proliferation, stem cell differentiation, and ...
Background. Numerous investigators have observed that pulmonary emboli are rapidly lysed in a canine model system. This study was undertaken to delineate the unique mechanism that accounts for the rapid dissolution of pulmonary emboli in mongrel dogs. Methods and Results. Canine plasminogen activator (PA) activity (2.6± 1.1 IU/mL acidified platelet-poor plasma [PPP], <0.3 IU/mL acidified whole ...
Background and purpose: Preventive orthodontics in mixed dentition requires accurate prediction for mesiodistal width of unerupted permanent teeth. In this study, we presented a software for prediction of unerupted permanent canine and premolar mesiodistal width that help orthodontist in precise treatment planning. Material and Methods: For this cross-sectional study, we scanned alginate impre...
The presence of insufficient bone volume remains a major clinical problem for dental implant placement to restore the oral function. Gene-transduced stem cells provide a promising approach for inducing bone regeneration and enhancing osseointegration in dental implants with tissue engineering technology. Our previous studies have demonstrated that the hypoxia-inducible factor-1α (HIF-1α) promot...
BMI1, a stem cell factor and member of the polycomb group of genes, has been shown to contribute to growth and chemoresistance of several human malignancies including primary osteosarcoma (OSA). Naturally occurring OSA in the dog represents a large animal model of human OSA, however the potential role of BMI1 in canine primary and metastatic OSA has not been examined. Immunohistochemical staini...
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target selectivity and potency compared to ibrutinib. In this study, we evaluated acalabrutinib in spontaneously occurring canine lymphoma, a model of B-cell malignancy similar to human diffuse large B-cell lymphoma (DLBCL). First, we demonstrated that acalabrutinib potentl...
Canine ehrlichiosis is a very important emerging disease in India. This study is the first attempt screening a large number of canines in India for the detection of canine monocytic ehrlichiosis. In the present study, 510 blood samples of dogs were screened for the presence of Ehrlichia canis and other variants of Anaplasmataceae family by serological and molecular methods.Out of the 510 serum ...
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