The potassium aluminyl [K{Al(NONDipp)}]2 ([NONDipp]2−=[O{SiMe2NDipp}2]2−, Dipp=2,6-iPr2C6H3) activates ethene towards carbonylation with CO under mild conditions. An isolated bis-aluminacyclopropane compound reacted via of an Al−C bond, followed by intramolecular hydrogen shift to form K2[Al(NONDipp)(μ-CH2CH=CO-1κ2C1,3-2κO)Al(NONDipp)Et]. Restricting the chemistry a mono-aluminium system allowe...

Reactive oxygen species (ROS) play an important role in the development of various pathological conditions as well as aging. ROS oxidize DNA, proteins, lipids, and small molecules. Carbonylation is one mode of protein oxidation that occurs in response to the iron-catalyzed, hydrogen peroxide-dependent oxidation of amino acid side chains. Although carbonylated proteins are generally believed to ...

Sustained elevations in circulating glucocorticoids elicit reductions in skeletal muscle microvascular content, but little is known of the underlying mechanisms. We hypothesized that glucocorticoid-induced oxidative stress contributes to this phenomenon. In rats that were implanted with corticosterone (CORT) or control pellets, CORT caused a significant decrease in muscle glutathione levels and...

Different studies reported the presence of oxidized (carbonylated) albumin in the extravascular pool, but not in the intravascular one of cigarette smokers. In this study we attempted to explain this apparent discrepancy exposing human serum albumin (HSA) to aqueous cigarette smoke extract (CSE). CSE induces HSA carbonylation and oxidation of the HSA Cys34 sulfhydryl group. An antioxidant actio...

PURPOSE Oxidative stress plays a pivotal role in the pathogenesis of the metabolic syndrome and in the progression of its complications. Carbonylated proteins are a stable marker of severe oxidative stress because damage to the protein structure is irreversible and may cause an inhibition of their enzymatic activity or an increased susceptibility to proteolysis. There are few data regarding pro...

The overview describes the industrial application of homogeneous catalysts for the chemical industry. In the first part, some theoretical background is given on organometallic complexes and homogeneous catalysis followed by a description of the prerequisites and current problems for their industrial application. Selected examples of industrially useful catalysts for the manufacture of bulk and ...

Abstract Palladium‐catalyzed carbonylation reactions with Cr(CO) 6 as carbonyl source are key for the preparation of N ‐ynonylsulfoximines from H‐sulfoximines and bromoalkynes. The couplings proceed at room temperature a wide range substrate combinations affording corresponding products in good yields. magnified image

A single-Rh-site catalyst (Rh-TPISP) that was ionically-embedded on a P(V) quaternary phosphonium porous polymer evaluated for heterogeneous ethanol carbonylation. The [Rh(CO)I3]2– unit proposed to be the active center of Rh-TPISP carbonylation reaction based detailed Rh L3-edge X-ray absorption near edge structure (XANES), photoelectron spectroscopy (XPS), and extended fine (EXAFS) analyses. A...