lipopolysaccharide (lps) is an important structural component of the outer cell membrane complex of gram-negative microorganisms. its causative role in gram-negative bacteria-induced diseases and broad applications in different kinds of cell stimulation experiments provided a conceptual basis for studies directed at the isolation, purification, and detailed chemical characterization of lps. the...

Tumor cells produce tissue factor, cancer procoagulant, plasminogen activators and other factors that interact with the coagulation system, the fibrinolytic system and vascular or blood cells such that they can upset the normal homeostasis and balance between activation and inhibition of the coagulation and fibrinolytic systems. These activities play a role in tumor cell growth and metastasis, ...

context traumatic brain injury (tbi) is a leading cause of death, disability, and resource consumption per year. there are two kinds of brain injury in tbi, primary and secondary injuries. primary injury refers to the initial physical forces applied to the brain at the moment of impact. secondary injury occurs over a period of hours or days following the initial trauma and results from the acti...

Introduction Cold plasma is a self-sterilized, painless, and non-contact method in surgeries. These properties allow it to be applied to the living tissues and heat-sensitive parts. The aim of this study was to design a new cold plasma producer device and evaluate the effects of cold argon plasma on decreasing the coagulation time of blood drop in vitro and that of the injured liver blood in vi...

BACKGROUND In acute myeloid leukemia (AML), disseminated intravascular coagulation (DIC) contributes to morbidity and mortality, but the underlying pathomechanisms remain incompletely understood. METHODS We conducted a prospective study on 69 patients with newly diagnosed AML to further define the correlates of systemic coagulation activation in this hematological malignancy. Tissue factor pr...

Introduction Up regulation of coagulation factors is a less understood phenomenon in congestive heart failure. Existing literature supports the fact that levels of von Willebrand factor, fibrinogen, ICAM, PECAM, P-selectin, d-dimer, fibrinogen, vascular cell adhesion molecules and platelet aggregation are significantly elevated in congestive heart failure [1-8]. The most frequently noted compli...

hypercoagulable states are a group of conditions associated with an enhanced tendency toward blood clotting. although usual clinical manifestations of hypercoagulable states are thrombotic events such as deep venous thrombosis, hematoma can also occurs as a result of hypercoagulability in some patients. several inherited or acquired conditions may lead to hypercoagulable states. some of them in...

Dynamic Modeling of Cell-Free Biochemical Networks Using Effective Kinetic Models Report Title In this study, we present a novel modeling approach which combines ordinary differential equation (ODE) modeling with logical rules to simulate an archetype biochemical network, the human coagulation cascade. The model consisted of five differential equations augmented with several logical rules descr...

CONTEXT Preanalytical factors influencing the reliability of laboratory testing are commonplace. It is traditionally accepted that hemolytic samples are unsuitable for coagulation assays because of the release of hemoglobin, intracellular components, and thromboplastic substances from damaged blood cells. OBJECTIVE To evaluate the influence of blood cell lysis on routine coagulation testing. ...