discoidin domain receptor (ddr) is a new member of the receptor tyrosine kinase family. there are two isoforms of discoidin domain receptor (ddr), ddr1 and ddr2. these receptors play a major role in the adhesion, motility and cell proliferation. due to the important role of ddr2 in the development of tumor extension, this receptor is pivotal in the field of carcinogenesis. the aim of this study...

The widespread use of nanomaterials in vaccines, therapeutics, and industrial applications creates an increasing demand for understanding their ingestion by living cells. Researchers the field have called a more robust physical/chemical particle–cell interactions means to determine particles ingested per cell. Using superparamagnetic nanobeads, we measured beads cell quantified kinetics recepto...

the snp (rs11209026, arg381gln, r381q) in the il-23 receptor (il23r) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. we, therefore, investigated the association between il-23 r r381q gene polymorphism and asthma.this case-control study was performed on 209 patients, and 200 healthy controls...

Prostate cancer is a devastating disease for which current therapies are inadequate. Various lines of evidences have suggested the 5-lipoxygenase (5-LOX) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of Prostate cancer. Thus, search for new anti-cancer drugs targeting 5-LOX and leukotriene is very essential and important. The objective of the pre...

Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-DDT [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-DDE (2-2-bis(4/chlorophenyl)-1-1-di...

Abstract Glucocorticoids contribute to the daily migration patterns of T cells in well-nourished organisms and are elevated malnourished. We examined effect malnutrition on cell by comparing adoptively transferred malnourished control lymphoid organs recipients. found that generally entered tissues more efficiently than cells, regardless recipient. Strikingly, bone marrow recipients attracted n...

Calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. It has been reported that this protein has an apoptotic activity in tumor cells. Since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on HT29/219 and SW742 colon carcinoma and adenocarcinoma cell li...

HIGHLIGHTS Ischemia-reperfusion triggers acute kidney injury due to reactive oxygen species. Quercetin is an antioxidant flavonoid that modulate the Rennin-Angiotensin System. prevents tubular cell death, oxidation, and mitochondrial depolarization. interacts with angiotensin AT1 receptor.

Cell-to-cell and cell-to-environment communications are critical to the growth development of plants. Cell surface-localized receptor-like kinases (RLKs) mainly involved in sensing various extracellular signals initiate their corresponding cellular responses. As important vegetative organs for higher plants adapt a terrestrial living situation, roots play role survival It has been demonstrated ...