نتایج جستجو برای: cerebral cortex methamphetamine neurotoxicity

تعداد نتایج: 292796  

Journal: :Environmental science & technology 2005
Niladri Basu Anton Scheuhammer Nicole Grochowina Kate Klenavic Douglas Evans Mike O'Brien Hing Man Chan

Fish-eating wildlife, such as river otters (Lontra canadensis), accumulate mercury (Hg) at concentrations known to impair animal behavior, but few studies have explored the underlying biochemical changes that precede clinical neurotoxicity. The objective of this study was to determine if Hg exposure can be related to concentrations of neurochemical receptors in river otters. River otter carcass...

2014
Jennifer H. Hsieh Dan J. Stein Fleur M. Howells

Chronic methamphetamine abuse commonly leads to psychosis, with positive and cognitive symptoms that are similar to those of schizophrenia. Methamphetamine induced psychosis (MAP) can persist and diagnoses of MAP often change to a diagnosis of schizophrenia over time. Studies in schizophrenia have found much evidence of cortical GABAergic dysfunction. Methamphetamine psychosis is a well studied...

Journal: :IUBMB Life (International Union of Biochemistry and Molecular Biology: Life) 2004

Journal: :iranian biomedical journal 0
حمداله پناهپور hamdollah panahpour غلامعباس دهقانی gholam abbas dehghani

background: central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. our previous work showed that inhibition of angiotensin converting enzyme (ace) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (i/r) injuries. this study evaluated the impacts of post-ischemic inhibition of ace, enalapril, on brain inf...

Journal: :The American journal of psychiatry 2013
Javier Bernacer Philip R Corlett Pranathi Ramachandra Brady McFarlane Danielle C Turner Luke Clark Trevor W Robbins Paul C Fletcher Graham K Murray

OBJECTIVE Frontostriatal circuitry is critical to learning processes, and its disruption may underlie maladaptive decision making and the generation of psychotic symptoms in schizophrenia. However, there is a paucity of evidence directly examining the role of modulatory neurotransmitters on frontostriatal function in humans. In order to probe the effects of modulation on frontostriatal circuitr...

Journal: :Drug and alcohol dependence 2004
Raul Gonzalez Julie D Rippeth Catherine L Carey Robert K Heaton David J Moore Brian C Schweinsburg Mariana Cherner Igor Grant

Abuse of the stimulant drug methamphetamine is associated with neural injury and neuropsychological (NP) deficits, while the residual effects of marijuana use remain uncertain. We sought to determine if methamphetamine dependent persons who also met criteria for marijuana abuse or dependence evidenced different NP performance than those with dependence for methamphetamine alone. We examined thr...

Olig1 and Olig2, two transcription factors, play regulatory function in the differentiation and specification of oligodendrocyte progenitor cells (OPCs). In this study the effects of electromagnetic fields (EMF) on total protein concentration ( TPC ) and Olig1 and Olig2 expression in the cerebral cortex of mouse was examined. Twenty-one Balb/c mice were separated into three groups: control, EMF...

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