Oncostatin M receptor (OSMR) is commonly over-expressed in advanced cervical squamous cell carcinoma (SCC), producing a significantly worse clinical outcome. Cervical SCC cells that over-express OSMR show enhanced responsiveness to the major ligand OSM, which induces multiple pro-malignant effects, including increased cell migration and invasiveness. Here, we show that tissue transglutaminase (...

From December 2000 until 2010, the researchers at Royan Institute conducted a wide range of investigations on ovarian tissue cryopreservation with the intent to provide fertility preservation to cancer patients that were considered to be candidates for these services. In 2010, Royan Institute established the Royan Human Ovarian Tissue Bank as a subgroup of the Embryology Department. Since its i...

Müllerian ducts can form upper parts of normal female reproductive system and any failure in ductal fusion may lead to Müllerian Duct Anomalies (MDA). We present a case of MDA, a uterus dysplasia with no evidence of cervical or upper vaginal tissue. This case illustrates the role of Magnetic Resonance Imaging (MRI) on MDA diagnosis and urges the need for a unified reliable and practical classif...

Aberrant activation of the Wnt/β-catenin signaling axis is a prominent oncogenic mechanism in numerous cancers including cervical cancer. Wnt inhibitory factor-1 (WIF1) is a secreted protein that binds Wnt and antagonizes Wnt activity. While the WIF1 gene is characterized as a target for epigenetic silencing in some tumor types, WIF1 expression has not been examined in human cervical tissue and...

Cervical immobilisation is commonly applied following trauma, particularly blunt head injury, but current methods of immobilisation are associated with significant complications. Semi-rigid disposable cervical collars are known to cause pressure ulcers, and impede effective airway management. These collars may also exacerbate a head injury by increasing intracranial pressure as a result of exte...

In this short note we briefly introduce a newly developed image processing chain for a 3D reconstruction of serially sectioned tissue specimens. Provided a stack of digitised transmitted light microscope colour images of cervical tissue specimens, the procedure finally results in a 3D quantification and visualisation of the tumour invasion front of the respective cervical tumour within the spec...

Spatial frequency spectra from cervical intraepithelial neoplasia (CIN) tissues are used to detect differences among different grades of human cervical tissues. The randomness of the structures of tissues from normal to different stages of CIN tissues is recognized by analyzing the spatial frequency. This study offers a simpler and better way to recognize the alterations among normal and differ...