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MBX-102/JNJ-39659100 (MBX-102) is a selective, partial PPAR-γ agonist that lowers glucose in the absence of some of the side effects, such as weight gain and edema, that are observed with the TZDs. Interestingly MBX-102 also displays pronounced triglyceride lowering in preclinical rodent models and in humans. Although in vitro reporter gene studies indicated that MBX-102 acid is a highly select...

Two once-a-month preparations cyclo provera (Depo-medroxy Progesterone Acetate 25 mg and Estradiol Cypionate 5 mg) and HRP-102 (Norethisterone enanthate 50 mg and Estradiol Valerate 5 mg) were tried in two groups of women by random allocation, and their effectiveness, complaints and reasons for discontinuation were studied. A total of 206 women were admitted (104 on cyclo provera and 102 on HRP...

Jennie Johnstone, MD; Mark Loeb, MD, MSc; Koon K. Teo, MBBCh, PhD; Peggy Gao, MSc; Leanne Dyal, MSc; Lisheng Liu, MD; Alvaro Avezum, MD, PhD; Ernesto Cardona-Munoz, MD; Peter Sleight, MD; Robert Fagard, MD, PhD; Salim Yusuf, MD, DPhil; on behalf of the Ongoing Telmisartan Alone and in Combination With Ramipril Global EndPoint Trial (ONTARGET) and Telmisartan Randomized Assessment Study in ACE I...

The brown algae are an interesting group of organisms from several points of view. They are the dominant organisms in many coastal ecosystems, where they often form large, underwater forests. They also have an unusual evolutionary history, being members of the stramenopiles, which are very distantly related to well-studied animal and green plant models. As a consequence of this history, brown a...

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PURPOSE This phase Ib study evaluated the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of AMG 102, a fully human monoclonal antibody against hepatocyte growth factor/scatter factor (HGF/SF), in combination with bevacizumab or motesanib in patients with advanced solid tumors. EXPERIMENTAL DESIGN Patients with treatment-refractory advanced solid tumors were sequentially en...