The continuous presence of nerve growth factor (NGF) is thought to be required for the elaboration of neuronal-like traits in PC12 cells. Surprisingly, we find that a 1 min exposure to NGF is sufficient to engage a longer-term genetic program leading to the acquisition of membrane excitability. Whereas continuous exposure to NGF causes the induction of a family of sodium channels, the effect of...

The kinetics of toxicity of doxorubicin (Dox) and gold nanoparticle-conjugated doxorubicin (Au-Dox) were investigated in cultured B16 melanoma cells and cardiomyocytes using real-time cell-growth imaging. Both bolus exposure and continuous exposure were used. Modeling of the growth curve dynamics suggested patterns of uptake and/or expulsion of the drug that were different for the different cel...

The European Regulation 2003/10/EC, voted by the European Parliament in 2003, is implemented in most of the countries of the European Community since 2006. This regulation defines different actions to be taken by the employer when the employees are submitted to continuous or impulse noise which exceeds the lower or upper exposure action value. It also defines maximum exposure levels to which em...

PURPOSE To determine the relative contributions of inner and outer retinal photoreception to the pupillary light response. METHODS Wild-type, retinal degenerate (rd/rd), and melanopsin mutant (opn4(-/-)) mice were tested for pupillary light responsiveness by video pupillometry before, during, and after exposure to supersaturating light intensities. Similar lighting protocols were used to prob...

riety of human malignancies. CDDP is a well-known DNAdamaging agent, and it is currently thought that DNA platination is an essential first step in its cytotoxic activity. Recent evidence has shown that apoptosis is a marker of tumor cells that have been exposed to CDDP. In addition, CDDP has been reported to induce apoptosis at higher concentrations than the clinical dose. The CDDP is a type o...

This paper investigates the behavior of reinforced concrete continuous flat slabs after exposure to fire through experimental and theoretical analysis investigations were made. In the experimental part a series of tests carried out, to evaluate the effect of fire on the mechanical properties of concrete including a number of cubs and cylinders. Indirect fire exposure experiments are performed i...

all living organisms are exposed to ionizing radiation comprising cosmic rays coming from outer space, terrestrial nuclides occurring in the earth’s crust, building materials, air, water and foods and in the human body itself. the exposures are constant and uniform for all individuals everywhere including the dose from ingestion of 40k in food. cosmic rays are, more intense at higher altitudes,...

introduction:. nickel (ni) is one of the toxic heavy metals that exposure to it has been connected with chronic respiratory complications such as asthma, chronic bronchitis, lung cancer and heart diseases .. in this research,  original studies that investigated occupational or environmental exposures to nickel and  measured nickel levels in human tissues was reviewed. materials and methods: in ...

testicular cancer is one of the commonest cancers in men of working age, and is increasing in incidence in europe and north america. one suggested mechanism of causation is that there is impaired differentiation of germ cells in the pre- or perinatal period, followed by malignant transformation in later life, possibly by a hormonal mechanism. endocrine disrupting chemicals (edcs) have been a ma...