Unilateral brain damage which includes the hippocampus leads to memory impairments consistent with hemispheric specialization on the same side. Damage to the corpus callosum, the major connecting pathway between the left and right hemispheres, also leads to memory impairments. This suggests both hemispheric specialization on the hippocampal level and a critical role for the corpus callosum in m...

The effect of prenatal malnutrition on the anatomy of the corpus callosum was assessed in adult rats (45-52 days old). In the prenatally malnourished animals we observed a signifi cant reduction of the corpus callosum total area, partial areas, and perimeter, as compared with normal animals. In addition, the splenium of corpus callosum (posterior fi fth) showed a signifi cant decrease of fi ber...

The mouse strain ddN from Japan was crossed with three other inbred strains prone to absence of the corpus callosum (BALB/cWah1, I/LnJ and 129/ReJ), and at least one brain with abnormally small corpus callosum was observed in offspring from each F1 hybrid cross. Data for several polymorphic protein markers revealed that the four strains are not closely related genetically. Nevertheless, they sh...

BACKGROUND The corpus callosum (CC) is a cerebral structure that reflects cognitive status in several neurological pathologies. Visual inspection of MRI has shown that hypoxic-ischemic encephalopathy(HIE) causes callosal damage. PRIMARY OBJECTIVE To quantify the CC surface in a sample of patients with antecedents of HIE and a group of matched controls. RESEARCH DESIGN Comparisons of CC meas...

In recent years many workers have studied the morphology of the adult corpus callosum and controversy exists regarding genderand ageassociated differences. Callosal size may vary due to differences in the number and size of nerve fibers, glial cells and blood vessels. However, very little is known about the fiber composition of the human corpus callosum and how this might affect the length and ...

BACKGROUND Alcoholism has been repeatedly associated with gray and white matter pathology. Although neuroimaging has shown alcoholism-related brain volume reductions and axonal compromise, the integrity of white matter volumes in chronic alcoholism has been challenging to measure on a regional level. METHODS We first examined the effects of alcoholism on cerebral white matter volumes by lobar...

BACKGROUND AND PURPOSE Agenesis of the corpus callosum, even when isolated, may be characterized by anatomic variability. The aim of this study was to describe the types of other forebrain commissures in a large cohort of randomly enrolled fetuses with apparently isolated agenesis of the corpus callosum at prenatal MR imaging. MATERIALS AND METHODS All fetuses with apparent isolated agenesis ...

Intracranial lipomas (iLp) are very rare congenital malformative lesions, being less than 0.1% of intracranial tumors [1]. They originate from abnormal differentiation of the mesenchimal tissue of meninx primitiva [2–4]. Intracranial lipomas mainly localize in the pericallosal zone, where they are mostly asymptomatic, being frequently associated to other defects of differentiation of the midlin...