background and aim: in spite of the effect of the left hemisphere domination on first langu­age acquisition in human, studies suggest activi­ties and the role of both hemispheres in learning second language. therefore learning a second language requires more communication between the two hemispheres. regarding the role of the corpus callosum as the only data-centric inter­face between the two h...

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introduction: interhemispheric transmission of signal is done by corpus callosum (cc) as the largest fiber tract in brain. cc comprised 5 segments of rostrum, genu, body, isthmus, and splenium. contradictory reports exist about sexual dimorphism of cc. we designed this study to assess probable sexual differences of cc and its different parts in men and women. methods: we analyzed magnetic reson...

Background: Bone marrow mesenchymal stem cells (BM-MSCs) elicit neuroprotective effects, and their repair ability has been investigated in different experimental models. We aimed to investigate the effect of multiple i.p. BM-MSCs injections in the cuprizone model of multiple sclerosis in mice. Methods: Adult male C57BL/6 mice (n = 40) were fed a regular diet or a diet containing cuprizone (0.2%...

background: x-linked lissencephaly with ambiguous genitalia (xlag) is a recently described genetic disorder, in which patients present with lissencephaly, agenesis of the corpus callosum, refractory epilepsy of neonatal onset, acquired microcephaly, and male genotype with ambiguous genitalia. xlag is responsible for a severe neurological disorder of neonatal onset in boys. a gyration defect con...

Background Corpus callosum is the largest commissure in human brain. It consists of tightly packed white matter tracts connecting the two cerebral hemispheres.  In this study we aimed to evaluate role of fiber tractography (FT), and diffusion tensor imaging (DTI) in ped...

previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (mscs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (ms). the aim of this study was to examine the effects of co-administration of 17β-estradiol (e2) and adipose-derived mesenchymal stem cells (adscs) on remyelination of corpus callosum axons in a cuprizone model of ms. for...