In cross docking strategy, arrived products are immediately classified, sorted and organized with respect to their destination. Among all the problems related to this strategy, the vehicle routing problem (VRP) is very important and of special attention in modern technology. This paper addresses the particular type of VRP, called VRPCDTW, considering a time limitation for each customer/retai...

We consider in this article the Two-Machine Cross-Docking Flow Shop problem, which is a special case of scheduling with typed tasks, where we have two types of tasks and one machine per type. Precedence constraints exist between tasks, but only from a task of the first type to a task of the second type. The precedence relation is thus a directed bipartite graph. Minimizing the makespan is stron...

Cross docking is a warehouse management concept in which items delivered to a warehouse by inbound trucks are immediately sorted out, reorganized based on customer demands and loaded into outbound trucks for delivery to customers, without requiring excessive inventory at the warehouse. Compared to traditional warehousing, the storage as well as the length of the stay of a product in the warehou...

The Transportation Research Forum, founded in 1958, is an independent, nonprofit organization of transportation professionals who conduct, use, and benefit from research. Its purpose is to provide an impartial meeting ground for carriers, shippers, government officials, consultants, university researchers, suppliers, and others seeking exchange of information and ideas related to both passenger...

In this paper, we propose an extension of the vehicle routing problem with crossdocking that takes into account resource constraints at the cross-dock. These constraints limit the number of docks that can be used simultaneously. To solve this new problem, we adapt a recently proposed matheuristic based on large neighborhood search. In particular, we focus on the feasibility tests for insertions...

Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...

Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...

different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

objective(s): recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. the ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. therefore, in the present study, a series of 19 compo...

A database consisting of 780 ligand-receptor complexes, termed SB2010, has been derived from the Protein Databank to evaluate the accuracy of docking protocols for regenerating bound ligand conformations. The goal is to provide easily accessible community resources for development of improved procedures to aid virtual screening for ligands with a wide range of flexibilities. Three core experime...