This study was designed to evaluate the utility of the bone markers total alkaline phosphatase (TAP), bone-specific alkaline phosphatase (BAP), aminoterminal propeptide of type I collagen (PINP), carboxyterminal propeptide of type I collagen (PICP), pyridinoline crosslinks (PYD), deoxypyridinoline crosslinks (DPD), cross-linked carboxyterminal telopeptide of type I collagen (ICTP), cross-linked...

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Interference by human anti-animal immunoglobulins, commonly referred to as heterophile antibodies, in immunologic assays is known to be an important consideration for medical testing laboratories (1–3). Although automated immunometric assays are formulated to reduce these effects, it is unlikely that complete elimination occurs (2 ), and artifactual results attributable to heterophile antibodie...