We report a case of progressive multifocal leukoencephalopathy developing in a fludarabine-naïve patient with chronic lymphocytic leukemia. We suggest that progressive multifocal leukoencephalopathy should be considered in any chronic lymphocytic leukemia patient with unexplained neurological symptoms. Treatment history does not necessarily require fludarabine. Intrathecal cytosine arabinoside ...

0,cular complications after smallpox vaccination are rare occurrences, but still may cause considerable morbidity. In some of the developing countries, vaccinia keratitis is still an important cause of blindness. Keratitis is the most serious ocular problem and occurs in about 20 to 30 per cent of ocular vaccinia. A diverse number of therapeutic regimes have been used in the treatment of ocular...

The combined effect of human lymphoblastoid interferon (HLBI) and anticancer agents on the growth of MOLT-4 was studied in vitro. The interferon showed a strikingly synergistic interaction in combination with aclarubicin, cytosine arabinoside or prednisolone. It was moderately synergistic in combination with adriamycin or 5-fluorouracil and tended to show additive effects with daunorubicin or v...

The effects of methotrexate and cytosine arabinoside on polyamine metabolism were studied in a rapidly proliferating leukemic tumor (LI210) in C57BL/6 X DBA/2 (hereafter called BDP!) mice. Methotrexate, the most effective antileukemic drug in terms of increasing the median survival time also was the most effective, both in inhibiting the enzymes in the polyamine biosynthetic pathway and in decr...

Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinosi...

Five patients in the blastic phase of chronic granulocytic leukemia with massive splenomegaly were treated by intraarterial splenic artery infusion of cytosine arabinoside. All patients had massive splenomegaly associated with pain and/or hypersplenism and were refractory to previous therapy. All 5 patients demonstrated responses to treatment, with reduction in spleen size as well as symptomati...

Addition of BrdUrd in combination with prednisolone to HSV1-transformed hamster embryo cells induces an alkaline phosphatase (AP). FdURd enhances, dThd reduces the inducing capacity of BrdUrd and prednisolone. Induction is prevented by addition of cycloheximide or of cytosine arabinoside. BrdUrd reduces transport and phosphorylation of exogenously applied labeled Urd, especially the amount of U...