PURPOSE There were a lot of reports regarding associations of polymorphisms in the estrogen receptor α (ESR1). with many disorders. But, those with constitutional delay of growth and puberty (CDGP) are not known. Our aim is to find out any association between CDGP and ESR1. METHODS In a total of 27 subjects, we compared 7 CDGP patients with 20 healthy controls with their heights and sexual ma...

objective: to compare sexual and behavioral puberty problems between intellectually disabled (id) and normal boys in yazd, iran. methods: in the present study, 65 intellectually disabled and 65 normal boys were included. the child behavior check list (cbcl) was used to investigate behavioral problems. in order to study sexual problems, a questionnaire that was designed by the researchers was ap...

Adrenocortical carcinoma (ACC) in pediatric and adolescent patients is rare, and it is associated with various clinical symptoms. We introduce the case of an 8-year-old boy with ACC who presented with peripheral precocious puberty at his first visit. He displayed penis enlargement with pubic hair and facial acne. His serum adrenal androgen levels were elevated, and abdominal computed tomography...

It has been reported that the final height in short children is strongly related to the height at the onset of pubertal development, and pubertal heiht gain in GH-treated children is not exceed the gain in normal children. Therefore, it is now the consensus that insufficient height at the onset of puberty leads to short final height. We have already demonstrated that the final height in GH-defi...

Most children explore various aspects of gender and sexuality as children. Youth with consistent, persistent, and insistent gender non-conformity or gender dysphoria are important to identify in the pre- and early-pubertal years as early intervention and support may be lifesaving. Those whose gender non-conformity persists into puberty and adolescence are most likely to identify as transgender....

OBJECTIVE To assess whether, in girls with early onset of puberty, low birth weight is a risk factor for rapid progression to menarche and for short adult stature. DESIGN Longitudinal clinical assessment of 54 Catalan (Northern Spanish) girls followed from early onset of puberty (onset of breast development between 8.0 and 9.0 years of age) to final height. The timing of menarche and the fina...