نتایج جستجو برای: dendritic scaffold
تعداد نتایج: 78546 فیلتر نتایج به سال:
TLR agonist rHP-NAP as an Adjuvant of Dendritic Cell-Based Vaccine to Enhance Anti-Melanoma Response
Background: Melanoma is a common and malignant cutaneous tumor, which is responsible for a large proportion of skin cancer deaths. Dendritic cell (DC)-based vaccines have achieved positive results in the treatment of melanoma because of their ability to induce cytotoxic response to facilitate tumor elimination. Objective: To improve the efficacy of dendritic ce...
background: development of tissue engineering and regenerative medicine has led to designing scaffolds and their modification to provide a better microenvironment which mimics the natural niche of the cells. gelatin surface modification was applied to improve scaffold flexibility and cytocompatibility. methods: plla/pcl aligned fibrous scaffold was fabricated using electrospinning method. adscs...
blocking antibodies are valuable tools for inhibiting the specific receptor- ligand interactions. the interaction of co-stimulatory molecules on the antigen presenting cells with their ligands on t cells is an essential step for t cell activation. in the present study, the effect of blocking antibody against cd40 on its t cell stimulatory potential is investigated. the dcs (dendritic cells) wer...
dendritic cells (dcs) are a heterogeneous family of professional apcs involved in priming adaptive immune responses. donor dcs (direct pathway of allorecognition) and recipient dcs presenting processed donor major histocompatibility complex (mhc) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient t cell responses following organ tr...
dendritic cells (dcs) induce pathogen-specific t cell responses. we comprehensively studied the effects of addition of maturation stimulus, fibroblasts (fibroblast conditioned medium), pha activated t cells (t cell conditioned medium), and mixture of fibroblast & pha activated t cells (fcm-tccm) conditioned media on maturation of dcs. monocytes were cultured with gm-csf and il-4 for five da...
Introduction: Three-dimensional nano scaffolds by creating a three-dimensional structure similar to the body tissues have created a new perspective on cell culture and tissue repair. The aim of this study was to investigate the effect of polycaprolactone biodegradation scaffold (PCL) in treatment of diabetic wounds. Materials and Methods: Nano PCL-Gelatine scaffold was synthesized by electrospu...
بررسی میزان بقاء و رشد سلول های بنیادی CD93 بر روی داربست سه بعدی زیست تخریب پلی کاپرولاکتون- ژلاتین
Background and purpose: Application of three-dimensional scaffolds with the ability to simulate a three-dimensional in vivo environment has opened new perspective on targeted differentiation and therapeutic use of stem cells. In this study we examined the compatibility of CD93 stem cells with biodegradable pcl- gelatin scaffold. Materials and methods: In this experimental study, three-dimens...
Introduction: Age-related macular degeneration (AMD) is one of the retina diseases in which retinal pigment epithelium cells are degraded and lead to blindness. Available treatments only slow down the progression of it. In this study, human embryonic stem cells (hESCs) differentiated into retinal pigment epithelium cells were cultured on a polycaprolactone scaffold. Methods: The optimization o...
the innate immune system utilizes pattern recognition receptors (prrs) to recognize microbes. pathogens contain various molecules with diverse effects on immune response. in this study, we evaluated the effect of dna and protein components derived from two intracellular microorganisms including listeria monocytogenes (l.monocytogenes) and toxoplasma gondii (t. gondii) on dendritic cells (dcs) a...
background: bacterial dna has immunostimulatory effects on different types of immune cells such as dendritic cells (dcs). application of dcs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. objectives: to investigate the effect of tumor antigen pulsed dcs in the presence of cpg-1826 in treatment of a murine model of cancer. methods: ...
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