Although the major mechanisms of aerosol deposition in the lung are known, detailed quantitative data in anatomically realistic models are still lacking, especially in the acinar airways. In this study, an algorithm was developed to build multigenerational three-dimensional models of alveolated airways with arbitrary bifurcation angles and spherical alveolar shape. Using computational fluid dyn...

The influence of bacterial surface lipopolysaccharides (LPS) on cell transport and adhesion has been examined by use of three mutants of Escherichia coli K12 with well-characterized LPS of different lengths and molecular composition. Two experimental techniques, a packed-bed column and a radial stagnation point flow system, were employed to investigate bacterial adhesion kinetics onto quartz su...

Anti-phospholipid (aPL) antibodies are important contributors to development of thrombosis in patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE). The underlying mechanism of aPL antibody-mediated thrombosis is not fully understood but existing data suggest that platelets and the complement system are key components. Complement activation on platelets is seen in SL...

An experiment set-up is used to study wall deposition rate of particles on a rough surface in a turbulent channel flow. Deposition velocities for three classes of particles, namely, spherical glass particles, irregular shape polymer particles, and fibrous silicon particles are studied. The particle concentration at the test section was measured with the aid of an isokinetic probe in conjunction...

In this paper, kinetics of DC electrophoretic deposition EPD of carbon nanotubes CNTs is investigated. Carbon nanotubes suspended in pure ethanol with addition of magnesium nitrate was used as deposition media. The effect of main EPD parameters such as deposition time, applied voltage and the CNT concentration on deposit yield was investigated. The variation of current density vs. time and the ...

Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are unclear, yet clinically important. Drosophila is amenable to the study of cardiac ageing as well as collagen deposition; however it is un...