This report describes an integrated investigation of the refolding and reductive unfolding of insulin-like growth factor (IGF-I) and its variant, long R IGF-I (LRIGF-I), which has a Glu to Arg substitution and a hydrophobic 13-amino acid N-terminal extension. The refolding performed in glutathione redox buffer was quenched at different time points by adjusting the pH to 2.0–3.0 with a 1 N HCl s...

[reaction: see text] The synthesis of the C1-C13 fragment 3 of leucascandrolide A has been completed utilizing a stereoselective and regioselective reductive cleavage of a highly functionalized spiroketal to incorporate the cis-2,6-disubstituted tetrahydropyan. The spiroketal was constructed by addition of a lithiated pyrone 5 to aldehyde 6.

A comparative DNA scission activity study of azaferrocene, N-methyl-azaferrocene iodide and 3,3',4,4'-tetramethyl-1,1'-diphosphaferrocene (featuring iron in a +2 oxidation state), along with ferrocene (iron +2) and ferrocenium (iron +3) cation is described. Experiments indicate a high cleavage activity of azaferrocene and its N-methyl derivative in DMSO. DNA cleavage activity can be slowed down...

When fed the right food, hermit crab depicted in cover image grows bigger and finally needs a larger shell. This work reports reactivity of 1-phospha-2-azanorbornene, product hetero Diels-Alder reaction between 2H-phosphole an activated imine. Thus, reductive cleavage phosphorus−nitrogen bond with LiAlH4 leads to unprecedented ring expansion formation 1-phosphabicyclo[3.2.1]octa-2,5-diene. The ...