BACKGROUND Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is a skin cancer therapy that still has limitations due to the low penetration of this drug into the skin. We have proposed in this work a delivery system for 5-ALA based on liposomes having lipid composition similar to the mammalian stratum corneum (SCLLs) in order to optimize its skin delivery in Photodynamic Therapy (P...

Structure of the Skin Layers of the Skin Epidermis Dermis Subcutaneous Tissue Innervation and Blood Supply Manifestations of Skin Disorders Lesions, Rashes, and Vascular Disorders Pruritus Variations in Black Skin Skin Damage Caused by Ultraviolet Radiation Ultraviolet Rays Sunburn Drug-Induced Photosensitivity Sunscreens and Other Protective Measures Primary Disorders of the Skin Infectious Pr...

Background:Tissue-resident memory T (TRM) cells reside in peripheral tissues, including the skin. In humans, TRM exist both epidermis and dermis, but their composition, phenotype, function are not fully elucidated. To analyze skin needs to be incubated with Dispase II separate two layers. The next step varies among researchers; subsequent enzymatic digestion of dermis is popular, whereas sponta...

nevus lipomatosus cutaneous superficialis is a rare idiopathic hamartomatous anomaly of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. the classic, or solitary type, presents with asymptomatic soft, skin-colored to yellow papules or nodules. we report the case of a 12-year-old boy with congenital, classical nevus lipomatosus cuta...

As the largest organ in the human body, the skin has multiple functions of which one of the most important is the protection against various harmful stressors. The keratinised stratified epidermis and an underlying thick layer of collagen-rich dermal connective tissues are important components of the skin. The environmental stressors such as ultraviolet radiation (UVR) and pollution increase th...

Actinic Keratosis (AK) arises from sun-damaged skin and is the first clinical manifestation in the multistep process of skin carcinogenesis to invasive squamous cell carcinoma. Thus, it is an ideal target for chemopreventive efforts. Noninvasive measures of AK severity are needed to assess the efficacy of chemoprevention agents. We performed a pilot study on 20 participants to investigate the O...

Knowledge about the mechanical behaviour of the human skin can help to quantify the effectiveness of cosmetic products and to evaluate skin diseases and pressure sores. Besides that, information about mechanical properties can be used in numerical skin models. Philips is particularly interested in the mechanical behaviour of the skin for shaving research, to predict skin doming. This review wil...

The use of autograft skin is essential in the treatment of full thickness burns and large cutaneous defects. Both autograft thickness and condition of the wound bed modulate aesthetic and functional outcomes. Thicker autografts contract less and maintain greater functionality as the scar matures. The presence of hypodermis can also positively affect the eventual appearance and functionality of ...

scleroderma is a multisystem autoimmune connective tissue disease, cliaracterized by hardening of the skin. hv had 25 patients in the iranian pediatric unit of rheumatology over 10 years. there was female predominance if.m = 4/1, 80% female, 20% male). the age of onest was from 6 months to 16 years, the mean age being 10 years. the symptoms and signs were: nonpitting edema in 16%, liard skin in...