Current initiatives in Process Analytical Technology (PAT) and Quality by Design (QbD) are driving the need to identify and thoroughly understand the relation between Critical Process Parameters (CPP) and Critical Quality Attributes (CQAs)1. Design of Experiment (DOE) studies to test the effect of cell culture changes on post translational modifications of monoclonal antibodies (MAb) or to moni...

In this paper, a combined use of dimensional analysis (DA) and modern statistical design of experiment (DOE) methodologies is proposed for a hydrodynamics experiment where there are a large number of variables. While DA is well-known, DOE is still unfamiliar to most ocean engineers although it has been shown to be useful in many engineering and non-engineering applications. To introduce and ill...

Finned-tube heat exchangers are predominantly used in space conditioning systems, as well as other applications requiring heat exchange between two fluids. The design of finned-tube heat exchangers requires the selection of over a dozen design parameters by the designer such as tube pitch, tube diameter, tube thickness, etc... Finned-tube heat exchangers are common devices; however, their perfo...

Although experimentation is a frequent activity of engineers, they usually use primitive strategies to carry on their experiments. A survey identifies the needs of using an efficient and practical technique for the experimentation. Although Six Sigma improvement initiative emphasized the use of Design of Experiments (DoE) for experimentation, engineers still consider it a difficult technique to...

Submitted: Jul 22, 2013; Accepted: Sep 2, 2013; Published: Sep 11, 2013 Abstract: The purpose of this study is to determine the optimum condition of humidity contents, drying rate and energy in the experiment of drying of lemon grass in the fluidized bed dryer with presence of inert particles. The studied drying parameters were temperature, air velocity, mass of sand and drying time. The optimi...

In the present research era, high accuracy methods as a statistical analysis tool are increasing. Therefore, researchers more focused to produce reliable and accurate results. Hence, use of data modeling techniques is meet needs current trend. On other hand, Design Experiment (DOE) extensively used among various scientific fields; however, its limitations do not allow these study designs for pu...