BACKGROUND In the most patients with differentiated thyroid carcinoma (DTC), recurrent disease occurs in the neck region, but the usefulness of neck ultrasound (US) in its diagnosis is not clear. The aim of this study was to evaluate the significance of US in the detection of neck recurrence in low-risk DTC patients at first follow-up visits. MATERIAL AND METHODS A total of 32 patients, who h...

OBJECTIVE Measurement of recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin (Tg) is generally recommended 72 h after the second rhTSH injection. However, due to the acute effect of I-131 on thyrocytes, Tg measured after radioiodine therapy (RIT) would not accurately reflect the thyroid tissue burden. We aimed to determine predictive values of serum Tg level measured just before rhTS...

OBJECTIVE Radioiodine ((131)I) is considered an effective and low-risk therapeutic radionuclide for differentiated thyroid carcinoma (DTC); however, dilemmas exist in the optimization of indications, pre-treatment thyroid stimulating hormone (TSH) stimulation, dose decision, as well as in the treatment of (131)I-refractory disease. Refined strategies on (131)I treatment for DTC based on late ev...

RATIONALE Iodine-131 (I-131) is a sensitive marker for the detection of differentiated thyroid cancer (DTC). I-131 whole-body scintigraphy (WBS) has been used widely in evaluation of DTC patient. However, I-131 WBS exists many false-positive uptake of I-131 because radioiodine uptake can also be seen in healthy tissue or in a variety of benign and malignant non-thyroidal tumors. PATIENT CONCE...

Objective. To present a complicated case of differentiated thyroid carcinoma (DTC) with metastases to the skull that was evident on I-131 whole body scan (WBS) but negative on other imaging modalities in a low risk patient. Methods. We will discuss clinical course, imaging, pathological findings, and treatment of the patient with skull metastasis from DTC. Pertinent literature on imaging and pa...

Serum thyroglobulin (Tg) and Tg antibody (TgAb) levels, together with neck ultrasonography and 131I whole-body scintigraphy (WBS), are diagnostic tools for postoperative follow-up of patients with differentiated thyroid carcinoma (DTC). Generally, good correlation is seen between Tg and WBS in follow-up studies for DTC after thyroid remnant ablation. Undetectable serum Tg with negative WBS resu...

BACKGROUND Concern regarding the health-related quality of life (HRQOL) of long-term survivors of thyroid cancer has risen due to the rapid increase in the incidence of thyroid cancer, which generally has an excellent prognosis. The aim of this study was to evaluate the status of HRQOL in disease-free survivors of differentiated thyroid carcinoma (DTC) and to evaluate the important determinants...

Thyroid cancer is the most common malignant endocrine tumour. Differentiated thyroid cancer (DTC) is a rare disease with increased incidence. In 2014, 62,980 (15,190 for males and 47,790 for women) cases of DTC were estimated in the US, compared to 2009 with 31,200 new cases [1]. In the US, estimated new cases for 2017 are 14,400 for males and 42,470 for females [2]. Thyroid cancer incidence ra...

While significant advances have been made in the past decade in the etiopathogenesis of differentiated thyroid cancer (DTC),1 advances in surgery have not been relevant. Thus, robot-assisted cervicoscopic techniques or procedures using approaches different from the conventional transverse cervicotomy have been developed.2 The practical value of these approaches is however very limited. One of t...

RATIONALE The early detection of recurrent differentiated thyroid carcinoma (DTC) cells in postsurgery DTC patients relies on the sensitivity of measuring both the level of thyroglobulin (Tg) and 131-iodine distribution on a whole-body scan (WBS). Recent studies have defined patients who subsequently have no evidence of disease as those who have a stimulated Tg level <1 ng/mL with no other radi...