background: a new biological dosimeter based on methemoglobin level was developed in this study. materials and methods: methemoglobin level in erythrocytes from mice subjected to γ rays from a 60co source was detected using the methemoglobin kit. the dose range was from 0.5 to 8 gy and the dose rate was 0.5 gy/min. results: the results demonstrate that methemoglobin level increases with increas...

background: the trabecular bone changes in the tibia of c3h/hen mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 gy) or 137cs-generated gamma-rays (0-6 gy). materials and methods: serum calcium, phosphorus, estradiol concentration and alkaline phosphatase activity were measured. tibiae were analyzed using microcomputed tomography. biomechanical...

Hormesis, a dose-response phenomenon characterized by a low-dose stimulation and a high-dose inhibition, has been the object of controversy due to its challenging of basic understandings of the dose-response relationship and implications for risk assessment. The author addresses issues relating to the definition of hormesis, the relationship of hormesis to risk assessment and risk management, a...