The main contribution of this paper is a bulk-loading algorithm for multi-way dynamic metric access methods based on the covering radius of a representative, like the Slim-tree. The proposed algorithm is sample-based, and it builds a height-balanced tree in a top-down fashion, using the metric domain’s distance function and a bound limit to group and determine the number of elements in each par...

background: drug delivery systems related to different cancer therapy is now expanding. chitosan (cs) is currently receiving enormous interest for medical and pharmaceutical applications due to its biocompatibility in animal tissues. in this study two nanogels were prepared from chitosan. some of the critical factors such as controlling the release, adsorption and specially targeting drug deliv...

The dense extracellular matrix (ECM) within the articular cartilage derives its compressive modulus from the electrostatic and osmotic interactions between highly charged glycosaminoglycan (GAG) chains. Furthermore, the structural integrity of the ECM comes from the tightly interwoven collagen network, which accounts for the tensile and shear stiffness of the cartilage. Due to the avascular, an...

The loading margin to a saddle-node orfold bifurcation is a useful and basic index of proximityto voltage collapse. Sensitivities of the loading margincan be used to select controls to avoid voltage collapse.This paper justifies the use of static power models to com-pute loading margins and their sensitivities. In particular,dynamic load models may be reduced to static e...

The annulus fibrosus (AF) of the intervertebral disc experiences cyclic tensile loading in vivo at various states of mechanical equilibrium. Disc degeneration is associated with alterations in the biochemical composition of the AF including decreased water content, decreased proteoglycan concentration, and increased collagen deposition that affect mechanical function of the AF in compression an...

biodegradable nanoparticulate carriers, have important potential applications for administration of therapeutic molecules. chitosan based nanoparticles have attracted a lot of attention upon their biological properties such as biodegradability, biocom-patibility and bioadhesivity. the aim of the present investigation was to describe the synthesis and characterization of novel biodegradable nano...

The aim of this study was to investigate the effects of serum and compressive dynamic loading on the cartilaginous matrix spatiotemporal distribution around chondrocytes in vitro. Murine chondrocytes suspended in agarose were cultured in serum-free media or in varying concentrations of serum with or without compressive dynamic loading. Gene expression was assayed by quantitative polymerase chai...

In an object oriented, distributed environment, program maintenance, which has never been the most predictable task, becomes even more uncertain. Java’s dynamic loading mechanism was developed to tackle some of the uncertainties. In doing so, it shifts the focus from the state of the sources to that of the binaries. This paper discusses some of the implications of that move.