February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

Hypertension is highly prevalent in Canada, affecting more than 20% of all adults. Thiazide diuretics have been shown in numerous studies to be effective agents for controlling blood pressure and reducing cardiovascular disease and death in hypertensive patients. Thiazide diuretics are recommended as initial first line therapy for uncomplicated hypertension in the 2003 Canadian Hypertension rec...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

Post-1980 U.S. data trace out a stable long-run money demand relationship of Cagan’s semi-log form between the M1-income ratio and the nominal interest rate, with an interest semi-elasticity of 1.79. Integrating under this money demand curve yields estimates of the welfare cost of modest departures from Friedman’s zero nominal interest rate rule for the optimum quantity of money that are quite ...

Central MessageThis new nomenclature and classification system for patients with a bicuspid aortic valve aims high but its complexity may be challenging in clinical settings.See Article page e383. This settings. See Drawing from his fascination Mount Everest expeditions, Winston Churchill used the term summit to describe high-level meeting between international powers define world order 20th ce...

To the Editor: Anemia has recently become an important issue in patients with heart failure, and in the January 21, 2003 issue of Circulation, 3 studies relating to this subject were published.1–3 In one of these studies, Ezekowitz et al1 showed that anemia is common and is an independent prognostic marker for mortality in community-based patients with congestive heart failure (CHF). To determi...