UNLABELLED Intracellular signaling connected to integrin activation is known to induce cytoplasmic Ca(2+) release, which in turn mediates a number of downstream signals. The cellular entry pathways of two closely related alphaherpesviruses, equine herpesviruses 1 and 4 (EHV-1 and EHV-4), are differentially regulated with respect to the requirement of interaction of glycoprotein H (gH) with α4β1...

UNLABELLED Infected peripheral blood mononuclear cells (PBMC) effectively transport equine herpesvirus type 1 (EHV-1), but not EHV-4, to endothelial cells (EC) lining the blood vessels of the pregnant uterus or central nervous system, a process that can result in abortion or myeloencephalopathy. We examined, using a dynamic in vitro model, the differences between EHV-1 and EHV-4 infection of PB...

Significant differences exist between the immunogenicity of different commercial vaccines, and these differences should be considered in product selection. It is difficult to identify vaccines that generate significant immune responses to respiratory viruses. Anti-equine herpes virus type 1 (EHV-1) abortion vaccines outperform EHV-1 respiratory vaccines and could be considered for prevention of...

Experiments to analyze the function of the equine herpesvirus 1 (EHV-1) glycoprotein gM homolog were conducted. To this end, an Rk13 cell line (TCgM) that stably expressed EHV-1 gM was constructed. Proteins with apparent M(r)s of 46,000 to 48,000 and 50,000 to 55,000 were detected in TCgM cells with specific anti-gM antibodies, and the gM protein pattern was indistinguishable from that in cells...

This chapter represents the state of the art at the time of release. Readers are encouraged to consult the link below for the version of this chapter with the most recent release date: Neither NEETRAC, GTRC, any member of NEETRAC or any cosponsor nor any person acting on behalf of any of them: a) Makes any warranty or representation whatsoever, express or implied, i. With respect to the use of ...

The objective of the current study was to compare the performance of 4 methods to quantify Equid herpesvirus 1 (EHV-1) by real-time polymerase chain reaction (PCR) in nasal secretions from experimentally and naturally infected horses. Nasal secretions were collected on the challenge day and daily thereafter for 13 days from 4 experimentally infected horses. Additional nasal swabs were collected...

Equine herpesvirus type 1 and type 4 (EHV-1 and EHV-4) cause infections of horses worldwide. While both EHV-1 and EHV-4 cause respiratory disease, abortion and myeloencephalopathy are observed after infection with EHV-1 in the vast majority of cases. Disease control is achieved by hygiene measures that include immunization with either inactivated or modified live virus (MLV) vaccine preparation...

Equine asthma is a common cause of poor performance in racehorses but it unclear if respiratory viruses contribute to its etiology. The objective the study was determine were associated with clinical signs and bronchoalveolar lavage fluid (BALF) cytology Thoroughbred racehorses. herpesviruses (EHV-1, 2, 4, 5) equine rhinitis A B (ERBV, ERAV) genomes quantified by qPCR nasopharyngeal, tracheal, ...

We recently determined the genome sequence of the Coccolithoviridae strain Emiliania huxleyi virus 86 (EhV-86), a giant double-stranded DNA (dsDNA) algal virus from the family Phycodnaviridae that infects the marine coccolithophorid E. huxleyi. Here, we determine the phylogenetic relationship between EhV-86 and other large dsDNA viruses. Twenty-five core genes common to nuclear-cytoplasmic larg...