In this paper, we develop a freight transportation model for railway network considering hazmat transportation issue. In the transportation system considered, different customers can request for carrying hazmat and non- hazmat boxes. It is assumed that the sequence of the trains in the network is known. The objective is assigning the non-hazmat boxes and hazmat boxes to wagons of the trains so ...

Brain-derived neurotrophic factor (BDNF) is synthesized by small neuron cell bodies in the dorsal root ganglia (DRG) and is anterogradely transported to primary afferent terminals in the dorsal horn where it is involved in the modulation of painful stimuli. Here we show that BDNF is released in the rat isolated dorsal horn after chemical stimulation by capsaicin or electrical stimulation of dor...

Transmitter exocytosis from the neuronal soma is evoked by brief trains of high frequency electrical activity and continues for several minutes. Here we studied how active vesicle transport towards the plasma membrane contributes to this slow phenomenon in serotonergic leech Retzius neurons, by combining electron microscopy, the kinetics of exocytosis obtained from FM1-43 dye fluorescence as ve...

Intraflagellar transport (IFT) is essential for the elongation and maintenance of eukaryotic cilia and flagella. Due to the traffic jam of multiple trains at the ciliary tip, how IFT trains are remodeled in these turnaround zones cannot be determined by conventional imaging. Using PhotoGate, we visualized the full range of movement of single IFT trains and motors in Chlamydomonas flagella. Ante...

Fluid flow around bluff bodies occurs in numerous fields of science and engineering, such as flows pass vehicles, cables, towers and bridges. These flows have been studied experimentally and numerically for the last several decades. The investigation of flow around high-speed trains is an important application of bluff bodies. Fluid flow, aerodynamic forces and moments, separation and wake regi...

Laback and Majdak (1) recently showed that interaural timedelay (ITD) sensitivity in bilateral cochlear implant (BiCI) users can be improved at high rates by diotic randomization of the electrical pulse timing. They ascribed their result to ‘‘restarting’’ of the binaurally adapted auditory system. However, an alternative explanation is that randomizing electrical pulse rate introduced low-rate ...

The locomotive assignment and the freight train scheduling are important problems in railway transportation. Freight cars are coupled to form a freight rake. The freight rake becomes a train when a locomotive is coupled to it. The locomotive assignment problem assigns locomotives to a set of freight rakes in a way that, with minimum locomotive deadheading time, rake coupling delay and locomotiv...

Passing underground trains induce vibrations transmitted to the ground surface and the nearby structures. Ordinarily, these vibrations do not result in structural damage but can harm nonstructural elements and disturb the occupants. These effects are more pronounced when evaluating buildings like hospitals, laboratories, museums, etc., and their assessment is an important design need. To respon...

During the last decades, the railway traffic in densely populated areas has increased. At the same time, passenger trains have become faster and freight trains have become heavier. Consequently, trains are an increasing source of ground vibration, which may be a nuisance to people, buildings and sensitive equipment. In this research, a two-dimensional dynamic system, including underground train...