To study anxiolytic and antidepressant effect of Astaxanthin as an adjuvant to standard drug.In this study, to investigate the effects of astaxanthin on anxiety and depression,we performed some behavioural trials including elevated plus maze test, hole-board test, forced swim test, and tail suspension test.Astaxanthin ( 3 mg/kg/day for 15 days, orally) significantly increased the time spent in ...

Female hooded-Lister rats received either sub-chronic phencyclidine (PCP) (2 mg/kg, n=20) or vehicle (1 ml/kg, n=20) i.p. twice daily for seven days, followed by a sevenday washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the sub-chronic PCP treated rats. Rats were then tested on the elevated plus maze and i...

The alteration of endogenous opiate alkaloids during fasting state was investigated in rats. The concentrations of morphine and codeine in the cortex, midbrain, pons plus medulla, cerebellum, adrenal gland and pancreas were measured using radioimmunoassay for the opiates following high pressure liquid chromatography. The morphine and codeine contents of fasting rats showed maximum elevated leve...

The aim of the present study was to evaluate, by means of a temporal pattern analysis, rat’s behavior in the elevated plus maze test. A specific software called THEME has been used. On the basis of an ethogram encompassing 24 behavioral elements, results demonstrated that 14 components represented the 98% of the displayed activities. 145 different temporal patterns have been detected; length di...

Thirty four healthy young male subjects performed symptom limited exercise on Bruce protocol on treadmill machine. Hyperventilation induced labile repolarisation ST-T abnormalities were observed in 2 whereas exercise induced ST changes (upsloping ST depression in 4 and horizontal ST depression in 1) were observed in 5 additional candidates. Changes were unaccompanied by symptoms or signs and qu...