The reason that a certain subgroup of acute myeloid leukemia (AML) patients with t(8;21) translocation (generating the AML1/ETO fusion gene) displays a poor survival remains elusive. The proto-oncogene c-kit is expressed in approximately 80% of AML cases. The kinase domain mutation of the c-kit gene, one of the most common gain-of-function mutations associated with t(8;21) AML, predicts higher ...

This work deals with the customer-supplier relationship and concerns offer definition in Engineer-To-Order situations (ETO), by adopting supplier point of view. In such cases, when relies simply on key design choices without a detailed design, there is specific risk (ETO-specific risk) that customer expectations cannot be fulfilled. kind addition to conventional risks (non ETO-specific involved...

Acute myeloid leukemia (AML) is characterized by an aggressive clinical course and frequent cytogenetic abnormalities that include specific chromosomal translocations. The 8;21 chromosomal rearrangement disrupts the key hematopoietic RUNX1 transcription factor, and contributes to leukemia through recruitment of co-repressor complexes to RUNX1 target genes, altered subnuclear localization, and d...

Leukemia-specific AML1/ETO transcripts are detectable in most patients with t(8;21) acute myelogenous leukemia (AML) in long-term remission. To understand the inconsistency between the clinical cure and the presence of "residual disease" at a molecular level, we separated and identified the cells expressing AML1/ETO by phenotype and function. Here we demonstrate that AML1/ETO transcripts are pr...

The role of NEFA in eating behaviour is still poorly known. Our objective was to examine whether etomoxir (ETO), an inhibitor of NEFA oxidation, or ( - )-hydroxycitrate (HCA), an inhibitor of lipogenesis which may indirectly stimulate NEFA oxidation, alters satiety. Post-lunch satiety was measured in eight normal-weight male subjects who were deprived of time cues and received on three occasion...

Modified Bellani plate atmometer has been offered as an alternative and simpler technique to combination-based equations to estimate evapotranspiration ~ET! rate from green grass surface. However, there is a lack of information on its’ accuracy in humid climates. The evaporation rate sEAd from one type of atmometer marketed under the brand name ETgage® ~or ETG! with a Number 30 green canvas cov...