A 45-year-old man was seen with a history of confusion and disorientation for 1 year, during which time he was unable to identify relatives. He was unable to cope at his work as a plasterer, noticed neck pain, dysphagia, and unexplained weight gain. His family reported that his sleep pattern had changed, describing his sleep as disturbed with episodes consistent with stridor, myoclonus (the vid...

Background: Antisynthetase syndrome (ASS) is characterized by inflammatory myopathy, interstitial lung disease, arthritis, mechanical hands and Raynaud phenomenon, among other features. Recent studies have shown that idiopathic myopathies (IIM) may develop cardiac involvement, either ischemic (coronary artery disease) or (myocarditis). We wonder if characteristic involvement (interstitial appea...

Background: Anti-NOR 90 autoantibodies (anti-NOR90 Ab) are that target nucleolar transcription factor 1 or hUBF, involved in of RNA polymerase I. These have been detected 6.1% patients with Systemic Sclerosis (SSc), but their clinical prognostic significance has not clearly defined. Anti-NOR90 Ab mostly associated limited scleroderma mild organ involvement and can also be found other rheumatic ...

Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune diseases (AID) characterized by muscle inflammation and weakness, often accompanied with other organ involvement, such as skin rash or interstitial lung disease (ILD). Myositis specific (MSA) myositis associated antibodies (MAA) can be detected in approximately 60% patients IIM. Besides, antibody titers ...

Dear Editor, Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a form of autoimmune encephalitis involving anti-NMDAR antibodies, which is specific to the NR1/NR2 heteromers of the NMDAR.1 To the best of our knowledge, herein we report the first case of anti-NMDAR encephalitis associated with systemic lupus erythematosus (SLE). A 33-year-old woman presented to our hospital with co...

Background Patients with immune-mediated inflammatory diseases (IMID), particularly if treated B-cell depleting therapies, show reduced humoral responses to SARS-CoV-2 vaccines and increased risk of severe COVID-19 (1,2). Since pre-exposure prophylaxis (PrEP) monoclonal antibodies against proved effective in preventing infection (3) the general population, PrEP could be used for passive immuniz...

Background Idiopathic inflammatory myopathies (IIM) is a rare heterogenous group of diseases with varying involvement muscle, skin, joints and lung. There paucity prospective cohort studies in IIMs from India which assess the treatment response clinico serological profile patients IIM. Objectives To describe clinical characteristics, autoantibody early IIM attending Rheumatology clinic tertiary...

P rognosis in rheumatoid arthritis (RA) depends critically on early diagnosis and timely treatment with immune modulating drugs. As a consequence, early referral and access of patients with suspected RA to rheumatologists is mandatory for the establishment of diagnosis and initiation of treatment. Measurement of antibodies to cyclic citrullinated peptide (CCP) is a new and highly specific test ...

Background Patients with autoimmune systemic diseases have an increased risk to contract infections and develop severe complications; in turn can reactivated worsen the disease itself a vicious circle. Thus, vaccination is main weapon prevent infectious represents important safe instrument of care for rheumatic patients that needs be further promoted. However, immunosuppressive drugs used treat...

Background: Idiopathic inflammatory myopathies are a heterogenous group of systemic autoimmune diseases. Several phenotypes have been linked to specific autoantibodies. Clinically amyopathic dermatomyositis with rapidly progressive interstitial lung disease, the most severe form ILD, is associated anti-MDA5 antibodies. However not all patients and positive antibodies develop this condition. Obj...