Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 1 THE ANTI-INFLAMMATORY RESPONSE IN MICE WITH CORONAVIRUSINDUCED ENCEPHALOMYELITIS by Kathryn Rydze Trandem A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Immunology in the Gradu...

Antigen-induced peripheral tolerance is potentially one of the most efficient and specific therapeutic approaches for autoimmune diseases. Although highly effective in animal models, antigen-based strategies have not yet been translated into practicable human therapy, and several clinical trials using a single antigen or peptidic-epitope in multiple sclerosis (MS) yielded disappointing results....

Brain-derived neurotrophic factor plays a key role in neuronal and axonal survival. Brain-derived neurotrophic factor is expressed in the immune cells in lesions of experimental autoimmune encephalomyelitis and multiple sclerosis, thus potentially mediating neuroprotective effects. We investigated the functional role of brain-derived neurotrophic factor in myelin oligodendrocyte glycoprotein-in...

Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin olig...

Animal models of neurodegenerative and inflammatory diseases, have greatly contributed to our understanding of human disorders such as multiple sclerosis (MS). These models play a key role in drug development and have led to novel therapeutic approaches to treat human diseases. Nevertheless, some studies showing efficacy of therapies in animal models have not translated well to the clinic. In p...

Multiple sclerosis is characterized by demyelination and chronic inflammation of the central nervous system. Extensive studies in the animal model experimental autoimmune encephalomyelitis have suggested that multiple sclerosis is an autoimmune disorder mediated by myelin-specific CD4 T cells secreting T helper type 1 cytokines and tumor necrosis factor alpha. This concept has been widely used ...

[This corrects the article DOI: 10.1371/journal.pone.0144847.].

Guano samples from 412 Brazilian bats were screened with real-time PCR for the virulence genes (eae, est, elt, stx1, stx2, ehxA, invA, bfpA, aggR) representing five intestinal pathotypes of Escherichia coli. From 82 pooled samples, 22% contained Escherichia coli DNA, and eae, est, bfpA, aggR were detected.